Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous chaAntibody-drug conjugates (ADCs) have become one of the fastest growing classes of targeted therapeutics. By combining the specificity of monoclonal antibodies with highly potent cytotoxic payloads, ADCs are designed…
Posters & Papers
This paper, a collaboration between SCIEX and KCAS Bio, presents comprehensive LC-MS workflows for the quantitative analysis of antibody-drug conjugates (ADCs). Using trastuzumab deruxtecan as a model ADC, the study demonstrates sensitive quantification of free payload, total antibody, and conjugated ADC, highlighting the analytical performance and broad dynamic…
Blogs
Over the past decade, drug conjugates have emerged as one of the most important innovations in pharmaceutical development. Rather than relying on a drug molecule to find its target on its own, conjugation technologies allow scientists to attach therapeutic payloads to carriers that improve delivery, targeting, stability, and efficacy.
Blogs
As drug development programs continue to expand into more complex therapeutic modalities and patient-centric clinical trial designs, bioanalytical laboratories are under increasing pressure to generate high-quality data from smaller, less invasive samples. Volumetric absorptive microsampling (VAMS) has emerged as a promising solution, offering a practical alternative to traditional blood…
June 30
- July 1
KCAS Bio will be attending the 14th Antibody Industrial Symposium (AIS), taking place June 30-July 1 in Montpellier, France. As a premier event in the antibody and therapeutic development sector, AIS offers a unique platform for scientific exchange, collaboration, and innovation. Our presence at AIS underscores our commitment…
Posters & Papers
This presentation, given at the 2025 AAPS PharmSci Conference by Dawn Dufield, PhD, Scientific Officer of Mass Spectrometry at KCAS Bio, reviews Bioanalytical Strategies for Therapeutic Drugs and Their Conjugates (ADCs, Oligos, siRNA, ASOs and AOCs/ARCs) by QqQ/HRMS. If you have any questions about these services or any…
KCAS Bio is excited to sponsor the upcoming Pharmaceutical & BioScience Society (PBSS) workshop “Pharmacokinetics in Drug Discovery and Development: Fundamentals, Applications and Case Studies,” on October 9th from 8:45am – 5:30pm PST in Foster City, California at the Crowne Plaza Hotel. Advanced Pharmacokinetics for Small Molecules…
KCAS Bio is happy to announce our participation in the 13th edition of the Antibody Industrial Symposium (AIS), taking place in Tours, France. As a premier event in the antibody and therapeutic development sector, AIS offers a unique platform for scientific exchange, collaboration, and innovation.
KCAS Bio participated in the AAPS National Biotechnology Conference (NBC), held from May 4 to May 7, 2025, in Boston. It was a productive event that allowed us to connect with sponsors, exchange ideas with peers, and present our latest work in bioanalytical science.
Posters & Papers
Discover in this poster presented by Jessica Pham at WRIB 2025 on the “Development and Optimization of a Quantitative Assay for an Investigational Anti-Malarial Monoclonal Antibody Drug Candidate in Human Whole Blood Using Volumetric Absorptive Microsampling (VAMS)”. If you have any questions about these services or any others…
As the field of biotherapeutics rapidly evolves, the development of advanced conjugated therapies such as Antibody-Drug Conjugates (ADCs), Antibody-RNA Conjugates (ARCs), siRNA/oligos, and antibody-peptide conjugates has gained significant momentum. These next-generation therapeutics offer promising efficacy and safety profiles for treating various conditions, including cancer, rare diseases, and in vaccine…
ADCs represent a promising class of targeted therapies, and understanding the intricacies of their analysis is crucial for their successful development. In this blog, we address common questions to guide you through the various considerations involved in ADC research and testing. We will cover key topics related to…