KCAS-blog-thumb_2024-06_Dawn-AIS June 20 - June 21

The age of therapeutic conjugation is upon us! Bioanalysis for support of next generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines and potentially many other diseases. Recently, we have seen…

WhosTheScientist_K-M_TN Blogs
Read article Georges Köhler and César Milstein: The birth of monoclonal antibodies

Georges Köhler and César Milstein: The birth of monoclonal antibodies They discovered the technique for monoclonal antibody production. They won the Nobel Prize in Physiology or Medicine in 1984. They directly led to the development of antibody-based therapies for a vast array of health conditions. Since their initial invention…

KCAS-blog-thumb_2024-05_Biopharma-LBA-Generic-PK-Assays Blogs
Read article Biopharma LBA Generic PK Assays: Reduces Development Time and Cost

A pharmacokinetic (PK) assays evaluate how the body affects a specific substance after administration which includes: absorption, biodistribution, metabolism, and excretion. Preclinical (or non-clinical) PK assays play a crucial role in drug development and typically focus on assessing drug safety and maximum tolerable dose. For the development of pre-clinical PK…

KCAS-blog-thumb_2024-05_Lyon-ALS Blogs
Read article Progress and Challenges in the Fight Against ALS

Charcot, Gehrig, Hawking: A Journey Through ALS When you hear the names Charcot, Gehrig, and Hawking, what comes to mind? These names are all linked by a shared thread: Amyotrophic Lateral Sclerosis, or ALS. ALS, also known as Charcot disease, is named after Jean-Martin Charcot, a neurologist from the Pitié-Salpêtrière…

KCAS-blog-thumb_2024-04_Neutralizing Antibody Assay 2 Blogs
Read article Neutralizing Antibody Assay Development: Cell-Based vs. Non-Cell-Based Assays

Neutralizing antibodies (NAbs) are a subset of Anti-drug antibodies (ADAs) that play an important role in understanding the efficacy and safety of a drug product. While most drugs are associated with low risk and do not require a validated NAb assay prior to testing Phase 3 samples, drugs associated with…

KCAS-blog-thumb_2024-05_Novel PK Bioanalytical Approach Blogs
Read article Novel PK Bioanalytical Approach Using a 1.5 plex Hybrid LC-MS/MS Assay for Quantification of ADCs/ARCs

The age of therapeutic conjugation is upon us! Bioanalysis for support of next-generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines, and potentially many other diseases. Recently, we have seen the…

KCAS-event_2024-04D_AAPS-NBC-Nassouh Blogs
Read article KCAS Bio Presents Results from Recent Validation of IP Panels on the Cytek Aurora in PBMCs in San Francisco during AAPS NBC

KCAS Bio is excited to invite you to join us this week in San Francisco, CA during AAPS NBC where Nassouh Mourabet will be giving a presentation entitled “Spectral Unmixing Impact Comparison Across Immunophenotyping Panels and Matrices”. Nassouh Mourabet is a Scientist III in the Flow Cytometry department at KCAS…

kcas-poster-presentation_wrib-2024 Blogs
Read article KCAS Bio Presents Poster on Automating Selection for ISRs at 18th Annual WRIB in San Antonio, TX

Those of you attending the 18th annual WRIB meeting in San Antonio, TX are invited to attend a poster presentation being given by members of the KCAS Bio team: Jack Rogers, Jessie Allen, Yoka Thomas, and Cheikh Kane. This project developed and characterized a novel algorithm for automated ISR selection…

WhosTheScientist_LH_TN Blogs
Read article Leonard Herzenberg: The father of modern flow cytometry

Leonard Herzenberg: The father of modern flow cytometry He is considered the father of flow cytometry. He was an interdisciplinary innovator. He was recognized for his social advocacy and mentorship. Leonard Herzenberg was one of the most influential immunologists of his time. Committed to interdisciplinary collaboration and innovation, he…

KCAS-event_2024-ASGCT Blogs
Read article Can automation of molecular assay data in a highly regulated environment improve quality and provide a competitive advantage?

Arguably the most groundbreaking new opportunities for the treatment of disease and injury are Cell and Gene Therapy Products (CGTP) or what the European Medicines Agency (EMA) call Advanced Therapy Medicinal Products (ATMPs). EMA has broken down ATMPs into three main types: Gene therapy medicines: these…

KCAS-blog-thumb_2024-04_Cyto Blogs
Read article Validation of Flow Cytometry Panels – Poster Presentation at CYTO2024

KCAS Bio is attending CYTO2024, the 37th annual Congress of the International Society for the Advancement of Cytometry in Edinburgh, Scotland! A great occasion to explore the latest advancements in cytometry science and to discuss our flow cytometry services with the community. At this edition, Alessandra Roberto, PhD…

KCAS-blog-thumb_2024-04-DawnDufield (1) Blogs
Read article Dawn Dufield with KCAS Bio to Present at the 18th Annual WRIB in San Antonio, TX

Dawn Dufield, PhD is the Scientific Officer for Mass Spectrometry and has been with KCAS Bio since 2018. Before joining KCAS Bio, she worked in the quantitative large and small molecule LC-MS/MS field for Pfizer for over 20 years. Dawn has been a pioneer in the Hybrid LCMS field and…