The world of medicine relies heavily on innovation, and Contract Research Organizations (CROs) are key players behind the scenes. But what exactly is a CRO, and why are these organizations so crucial to the development of new therapies and medical advancements? Let’s explore what CROs do and why they’re vital…

The Rise of Immune Cell Therapies and the Importance of Cell Profiling by Flow Cytometry Immunotherapy is revolutionizing patient care, both in traditional oncology applications as well as in autoimmune indications. The complex mechanism of action based on the enhancement or targeted suppression of immune responses is fraught with challenges;…

2020 was an odd year for everyone. In what felt like just days, it seemed everything had changed and the rules were being rewritten almost daily about how we would all be engaging with one another. We went from racking up travel, hotel stays and airmiles while visiting our customers…

The age of therapeutic conjugation is upon us! Bioanalysis for support of next generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines and potentially many other diseases. Recently, we have seen…

Georges Köhler and César Milstein: The birth of monoclonal antibodies They discovered the technique for monoclonal antibody production. They won the Nobel Prize in Physiology or Medicine in 1984. They directly led to the development of antibody-based therapies for a vast array of health conditions. Since their initial invention…

A pharmacokinetic (PK) assays evaluate how the body affects a specific substance after administration which includes: absorption, biodistribution, metabolism, and excretion. Preclinical (or non-clinical) PK assays play a crucial role in drug development and typically focus on assessing drug safety and maximum tolerable dose. For the development of pre-clinical PK…

Charcot, Gehrig, Hawking: A Journey Through ALS When you hear the names Charcot, Gehrig, and Hawking, what comes to mind? These names are all linked by a shared thread: Amyotrophic Lateral Sclerosis, or ALS. ALS, also known as Charcot disease, is named after Jean-Martin Charcot, a neurologist from the Pitié-Salpêtrière…

Neutralizing antibodies (NAbs) are a subset of Anti-drug antibodies (ADAs) that play an important role in understanding the efficacy and safety of a drug product. While most drugs are associated with low risk and do not require a validated NAb assay prior to testing Phase 3 samples, drugs associated with…

The age of therapeutic conjugation is upon us! Bioanalysis for support of next-generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines, and potentially many other diseases. Recently, we have seen the…

KCAS Bio is excited to invite you to join us this week in San Francisco, CA during AAPS NBC where Nassouh Mourabet will be giving a presentation entitled “Spectral Unmixing Impact Comparison Across Immunophenotyping Panels and Matrices”. Nassouh Mourabet is a Scientist III in the Flow Cytometry department at KCAS…

Those of you attending the 18th annual WRIB meeting in San Antonio, TX are invited to attend a poster presentation being given by members of the KCAS Bio team: Jack Rogers, Jessie Allen, Yoka Thomas, and Cheikh Kane. This project developed and characterized a novel algorithm for automated ISR selection…

Leonard Herzenberg: The father of modern flow cytometry He is considered the father of flow cytometry. He was an interdisciplinary innovator. He was recognized for his social advocacy and mentorship. Leonard Herzenberg was one of the most influential immunologists of his time. Committed to interdisciplinary collaboration and innovation, he…