This paper, a collaboration between SCIEX and KCAS Bio, presents comprehensive LC-MS workflows for the quantitative analysis of antibody-drug conjugates (ADCs). Using trastuzumab deruxtecan as a model ADC, the study demonstrates sensitive quantification of free payload, total antibody, and conjugated ADC, highlighting the analytical performance and broad dynamic…

KCAS Bio collaborated with Phenomenex to demonstrate how magnetic bead-enabled hybrid LC-MS workflows are advancing modern bioanalysis for increasingly complex biotherapeutics. The case study explores how magnetic bead-based affinity capture enhances selectivity, sensitivity, and multiplexing, enabling more reliable quantitation of modalities such as monoclonal antibodies, ADCs,…

Discover in this poster presented by Rathna Veeramachaneni, Ph.D. at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about the various developmental parameters to consider for fit-for-purpose validation of a novel multiplexed hybrid LC–MS/MS assay for the simultaneous quantitation of two abundant biomarkers in human heart tissue.

Discover in this poster presented by Andrew Bergdorf at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about how we developed a streamlined, high-throughput proteomics workflow for human heart tissue that reduces sample preparation time while maintaining robust and reproducible biomarker detection. Key optimizations in…

Discover in this poster presented by Amrit Chakravarty, Ph.D. at the AAPS National Biotechnology Conference in 2026 about a high-sensitivity bioanalytical workflow combining single-use tip-based online cleanup on the Evosep Eno platform with a microflow LC-MS/MS setup on a SCIEX Triple Quad 7500+. The approach enables robust…

Discover in this poster presented by Taylor Dufield at WRIB 2026 about a fit-for-purpose multiplex LC–MS/MS workflow combining online and offline anti-peptide immunoprecipitation that enables sensitive, selective quantitation of protein biomarkers and binding partners from a single digested tissue sample across multiple species using a validated ICH M10-aligned approach.

Discover in this poster presented by Ryan Darling at WRIB 2026 on how a validated hybrid immunoaffinity LC–MS/MS method using a surrogate peptide and 2D chromatography enables selective, sub-ng/mL quantitation of a KLK1 analog in human plasma, overcoming LBA limitations caused by near-identical endogenous KLK1. If you have…

Discover in this white paper a global collaboration between KCAS Bio and its strategic partner, Crux Biolabs, to harmonize and validate a standardized 15-color spectral flow cytometry panel for pan-leukocyte profiling across multiple sites. If you have any questions about these services or any others…

This presentation, given at the 2025 AAPS PharmSci Conference by Dawn Dufield, PhD, Scientific Officer of Mass Spectrometry at KCAS Bio, reviews Bioanalytical Strategies for Therapeutic Drugs and Their Conjugates (ADCs, Oligos, siRNA, ASOs and AOCs/ARCs) by QqQ/HRMS. If you have any questions about these services or any…

Discover in this poster presented by Shalini Gautam, PhD, at ICCS 2025, our work on the “Immunophenotypic Characterization of AML Blast Cells: A Pilot Study for Precision Therapeutic Targeting​.“ If you have any questions about these services or others offered by KCAS Bio, please fill out and submit…

Discover in this poster presented by Heather Evans, PhD, at ICCS 2025, our work on the “Global Validation of a Pan-Leukocyte Panel with Enumeration for Fresh Whole Blood​“. If you have any questions about these services or others offered by KCAS Bio, please fill out and submit the…

Discover in this poster presented by Dmitri Negorev at CYTO 2025 on the “Flow-cytometry based multiparametric profiling of neutrophil function”. If you have any questions about these services or any others offered by KCAS Bio, please feel free to contact us using the form below.