Molecular services, purpose-built expertise
The KCAS Bio team has over 100+ years of combined experience in molecular services to support pre-clinical and clinical trials in various species, developing and validating methods and analyzing samples from a wide range of matrices. Whether a method is transferred or requires method development and validation, KCAS Bio will listen and support the best path forward.
KCAS Bio adheres to FDA-GLP good laboratory practices for cell and gene therapies. Our new state-of-the-art facility has a unidirectional workflow with two dedicated preamplification areas and a dedicated post-amplification area.
Full array of molecular capabilities
KCAS Bio offers a complete array of genomics-based assays using modern platforms. From discovery, preclinical studies through clinical trials, KCAS Bio is a highly experienced provider in supporting advanced modalities. Our team has expertise in biodistribution studies, molecular genomics, pharmacokinetic/pharmacodynamic (PK/PD), and biomarkers. Our dedicated team works in a built-for-purpose laboratory and works closely with customers on their programs. Our scientists have worked with many types of drug candidates.
KCAS Bio offers real-time quantitative (qPCR) and reverse transcriptase PCR (ddPCR)
- Adeno-associated virus (AAV)
- CAR-T therapy
- Enzyme replacement therapy
- Lipid nanoparticles
- Targeted delivery mechanisms
qPCR & ddPCR experience
- Assessments of nucleic acid therapeutics, including biodistribution/shedding studies and quantitation of the transgene mRNA for gene and cell therapies
- VCN (vector copy number)
- Gene expression analysis
- Cytokine mRNA profiling in immune response
- Biomarker assessment
- CYP mRNA induction
More to the puzzle
KCAS Bio is rapidly embracing the advancement of using AI to support our teams in producing the highest quality data – to assure the highest levels of quality and integrity.
In addition to the services listed above, KCAS Bio also offers additional gene product expression product analysis via LC-MS, Hybrid LC-MS, flow cytometry, ELISA, MSD, Luminex and additional ligand binding platforms to support all phases of drug development.
Moreover, we have experience in cell-based neutralizing antibody assays, anti-drug antibody (ADA), protein product delivery vector, and bioanalysis by ion-pair liquid chromatography coupled with mass spectrometry (via LC-MS/MS) and IP-LC-UV.
Interested in Flow Cytometry? KCAS Bio provides custom assay development, validation, sample processing and consulting services for a wide variety of applications. We measure a variety of targets on a wide range of cells, including T cells, B cells, macrophages/monocytes, basophils, neutrophils, dendritic cells and cell-derived particles.
Tell us how we can help with your project
We've earned our reputation for delivering reliable, error-free data. We understand the importance of speed, flexibility, and consistency and only make promises we can keep.
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Agile, responsive, and easy to work with
We prepare and adapt our services based on a deep understanding of your drug development ambitions and wider business objectives.