ADC Roundtable: Bioanalytical Workflows, Sample Prep, & Instrumentation Insights

ADCs are one of the fastest-growing therapeutic classes in drug development, with 80+ candidates now in the clinical pipeline. But every ADC creates multiple bioanalytical questions: free payload, conjugated payload, total antibody, and beyond. Each requires its own sample prep strategy, extraction decisions, and sensitivity considerations.

In this roundtable, bioanalytical scientists from KCAS Bio and SCIEX share practical approaches to ADC quantitation by LC-MS/MS, from sample preparation tradeoffs to multiplexing strategies and instrumentation choices that impact your PK data. 

Learning Objectives:

✅How ADC structure shapes your bioanalytical strategy

✅ When to use IP vs. direct digest workflows

✅ Sample prep tradeoffs that impact your LLOQ

✅ How multiplexing reduces variability utilizing single sample volume

✅ What instrument sensitivity means for real-world ADC PK

The Expert Speakers:

Rathna Veeramachaneni, Ph.D. Director of Mass Spectrometry Bioanalysis – Development, KCAS Bio

Ebru Selen Staff Scientist, Pharma/Biopharma Quant, SCIEX

Ryan Darling Associate Director of Mass Spectrometry Bioanalysis Development, KCAS Bio

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