Posters & Papers
This case study describes the development and validation of an ELISA method to quantify total antibody (tAb) from PYX-201, an investigational antibody-drug conjugate (ADC) developed by Pyxis Oncology. The assay was validated in rat and monkey plasma and used to support preclinical studies and an IND filing. The method…
Posters & Papers
This case study describes the development and validation of an ELISA method to quantify total antibody (tAb) from PYX-201, an investigational antibody-drug conjugate (ADC) developed by Pyxis Oncology. The assay was validated in rat and monkey plasma and used to support preclinical studies and an IND filing. The method…
Posters & Papers
This article provides updated recommendations for the bioanalysis of antibody-drug conjugates (ADCs), reflecting more than a decade of advances in the field. Developed by the AAPS ADC Working Group, it addresses key considerations for quantifying total antibody, conjugated ADC, free payload, and drug-to-antibody ratio (DAR), as well as immunogenicity,…
webinars
ADCs are one of the fastest-growing therapeutic classes in drug development, with 80+ candidates now in the clinical pipeline. But every ADC creates multiple bioanalytical questions: free payload, conjugated payload, total antibody, and beyond. Each requires its own sample prep strategy, extraction decisions, and sensitivity considerations. In this…
News
KCAS Bio’s Rathna Veeramachaneni, PhD, will join the 4th Annual Virtual Phenomenex BioSymposium on September 15, sharing insights into advanced LC–MS/MS approaches for the bioanalysis of complex antibody conjugates. Advancing Bioanalysis for Complex Antibody Conjugates Rathna’s presentation, “Magnetic Bead-Enabled Hybrid and Enhanced Traditional LC–MS/MS Workflows for the Bioanalysis…
Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous chaAntibody-drug conjugates (ADCs) have become one of the fastest growing classes of targeted therapeutics. By combining the specificity of monoclonal antibodies with highly potent cytotoxic payloads, ADCs are designed…
Posters & Papers
This paper, a collaboration between SCIEX and KCAS Bio, presents comprehensive LC-MS workflows for the quantitative analysis of antibody-drug conjugates (ADCs). Using trastuzumab deruxtecan as a model ADC, the study demonstrates sensitive quantification of free payload, total antibody, and conjugated ADC, highlighting the analytical performance and broad dynamic…
Blogs
Over the past decade, drug conjugates have emerged as one of the most important innovations in pharmaceutical development. Rather than relying on a drug molecule to find its target on its own, conjugation technologies allow scientists to attach therapeutic payloads to carriers that improve delivery, targeting, stability, and efficacy.
Blogs
As drug development programs continue to expand into more complex therapeutic modalities and patient-centric clinical trial designs, bioanalytical laboratories are under increasing pressure to generate high-quality data from smaller, less invasive samples. Volumetric absorptive microsampling (VAMS) has emerged as a promising solution, offering a practical alternative to traditional blood…
June 30
- July 1
KCAS Bio will be attending the 14th Antibody Industrial Symposium (AIS), taking place June 30-July 1 in Montpellier, France. As a premier event in the antibody and therapeutic development sector, AIS offers a unique platform for scientific exchange, collaboration, and innovation. Our presence at AIS underscores our commitment…
Posters & Papers
This presentation, given at the 2025 AAPS PharmSci Conference by Dawn Dufield, PhD, Scientific Officer of Mass Spectrometry at KCAS Bio, reviews Bioanalytical Strategies for Therapeutic Drugs and Their Conjugates (ADCs, Oligos, siRNA, ASOs and AOCs/ARCs) by QqQ/HRMS. If you have any questions about these services or any…
October 9
- October 9
KCAS Bio is excited to sponsor the upcoming Pharmaceutical & BioScience Society (PBSS) workshop “Pharmacokinetics in Drug Discovery and Development: Fundamentals, Applications and Case Studies,” on October 9th from 8:45am – 5:30pm PST in Foster City, California at the Crowne Plaza Hotel. Advanced Pharmacokinetics for Small Molecules…