Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous chaAntibody-drug conjugates (ADCs) have become one of the fastest growing classes of targeted therapeutics. By combining the specificity of monoclonal antibodies with highly potent cytotoxic payloads, ADCs are designed…
Posters & Papers
This paper, a collaboration between SCIEX and KCAS Bio, presents comprehensive LC-MS workflows for the quantitative analysis of antibody-drug conjugates (ADCs). Using trastuzumab deruxtecan as a model ADC, the study demonstrates sensitive quantification of free payload, total antibody, and conjugated ADC, highlighting the analytical performance and broad dynamic…
Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous challenges associated with using LC-MS/MS for the bioanalysis of oligonucleotides that have slowed its utilization for these assays. These include: However, the increased adoption of LC-MS/MS for oligonucleotides…
Posters & Papers
KCAS Bio collaborated with Phenomenex to demonstrate how magnetic bead-enabled hybrid LC-MS workflows are advancing modern bioanalysis for increasingly complex biotherapeutics. The case study explores how magnetic bead-based affinity capture enhances selectivity, sensitivity, and multiplexing, enabling more reliable quantitation of modalities such as monoclonal antibodies, ADCs,…
Posters & Papers
Discover in this poster presented by Rathna Veeramachaneni, Ph.D. at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about the various developmental parameters to consider for fit-for-purpose validation of a novel multiplexed hybrid LC–MS/MS assay for the simultaneous quantitation of two abundant biomarkers in human heart tissue.
Posters & Papers
Discover in this poster presented by Andrew Bergdorf at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about how we developed a streamlined, high-throughput proteomics workflow for human heart tissue that reduces sample preparation time while maintaining robust and reproducible biomarker detection. Key optimizations in…
Posters & Papers
Discover in this poster presented by Amrit Chakravarty, Ph.D. at the AAPS National Biotechnology Conference in 2026 about a high-sensitivity bioanalytical workflow combining single-use tip-based online cleanup on the Evosep Eno platform with a microflow LC-MS/MS setup on a SCIEX Triple Quad 7500+. The approach enables robust…
Videos
Full laboratory tour of the KCAS Bio location in Kansas City, KS USA. Interested in speaking with one of our experts? Fill out the form below to connect with a KCAS Bio scientist.
Videos
The SCIEX 7500+ system offers ultrasensitive quantitation, rigorously tested on challenging matrices. It ensures reliable detection of low-level compounds in complex samples while minimizing downtime. Featuring: Rathna Veeramachaneni, Ph.D. Interested in speaking with one of our experts? Fill out the form below to connect with…
Videos
The Thermo Fisher Scientific Orbitrap 240 offers high-resolution mass spectrometry with unmatched sensitivity and superior mass accuracy for targeted and untargeted quantitation. It provides fast, reproducible results, streamlines workflows, and supports a wide range of applications, from small molecules to complex biomarker analysis, with enhanced data processing for quicker…
Blogs
Accurately quantifying cisplatin in human plasma by LC-MS/MS can be challenging due to matrix effects caused by endogenous plasma components, particularly in hemolyzed samples. At WRIB 2025, scientists from KCAS Bio and Lilly presented a novel bioanalytical approach designed to…
Blogs
Oligonucleotide therapeutics continue to reshape drug development by targeting disease pathways at the genetic level. Antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and antibody-RNA conjugates (ARCs) are expanding the range of treatable diseases, particularly for targets that were previously considered inaccessible to conventional therapeutics. As these modalities evolve,…