PATTERN_BLUE_1320x780 Blogs
Read article Overcoming Analytical Challenges in Oligonucleotide

In the world of scientific research and development, certain analytes pose unique challenges that require specialized expertise to overcome. Oligonucleotides, a class of analytes consisting of short DNA or RNA sequences, are notorious for their complexity and demanding nature. With their increasing importance in the…

PATTERN_BLUE_1320x780_2 Blogs
Read article FlowMetric and Cytek Partner on Flow Cytometry

Business Wire – May 24, 2023 11:00 AM EST – In an effort to continue…

KCAS-blog-thumb_2023_Navigating-Growth Blogs
Read article KCAS Growth: Navigating Company Expansion with Integrity and Engagement

Clinical research carries significant risks and numerous obstacles that must be overcome to achieve success. Identifying the ideal Contract…

KCAS-blog-thumb_2023-03_neuro-diseases Blogs
Read article Hope in motion: Monitoring Drug Efficacy for Neurodegenerative Diseases

Neurodegenerative diseases affect millions worldwide. Fifty million people are living with Alzheimer’s disease or other dementias. Although Alzheimer’s disease is one of the most recognized, it is just one of many neurological disorders, such as Multiple Sclerosis, Parkinson’s, or Huntington’s disease. These conditions lead to a…

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Read article The ICH M10 Guideline as the Gold Standard

ICH M10 (International Committee of Harmonization Multidisciplinary guideline) provides guidance on bioanalytical method validation and study sample analysis for the measurement of chemical and biological human drugs and their metabolites in biological samples. Such pharmacokinetic/toxicokinetic data serve as the basis for regulatory decisions on the safety, dosage, and…

KCAS-blog-thumb_2023_kcas-flow-for-cgt Blogs
Read article Molecular Bioanalysis for Cell and Gene Therapies

Being that it is a relatively “niche” segment of the industry, there are several key areas that need to be considered in the field of molecular services related to cell and gene therapies. First and foremost, it is important to recognize that regulatory guidelines within this field are…

KCAS-blog-thumb_2023_02-KCAS-ADCs-with-Hybrid Blogs
Read article Antibody Drug Conjugate Services from KCAS and What Hybrid Technology Contributes

Anyone who has been following KCAS for any amount of time has likely heard us discuss the advantages of Hybrid LC-MS/MS for the bioanalysis of large molecules. As pioneers in the technology for many years, KCAS has become a strong proponent of working with our customers to demonstrate the quality…

PATTERN_AMBER_1320x780_2 Blogs
Read article Guiding the Way: Creating a Roadmap for Your Functional Assays

Understanding the interactions between drugs and biological systems is critical for the success of a new drug. One key tool in this process is functional assays. Functional assays are customized assays that evaluate the impact of drugs on the functionality of cells. They test for a drug’s specific biological mechanism…

KCAS-blog-thumb_2023_01-B_Viral-Vectors-1 Blogs
Read article The Role Bioanalysis is Playing in Support of Viral Vector Drug Development

In 2022 we had 42 FDA Drug Approvals and 3 were Gene Therapies using a viral vector.  2 of the approvals in 2022 were AAV based.  The third is manufactured by adding functional copies of the transgene to the patient’s own Hematopoietic Stem Cells (HSCs)…

PATTERN_AMBER_1320x780 Blogs
Read article A Look Back and a Look Forward: KCAS is Prepared for the Next Ride in 2023

With 2022 firmly planted in our rearview mirror, and the planning for the new year essentially complete, we all look forward to a new year with cautious optimism as we wait to…

KCAS-blog-thumb_2022_GLP-CGT Blogs
Read article The Role of GLP Toxicology Studies in Bioanalysis for CGT

Cell and Gene Therapies (CGTs) has an estimated market size value in 2022 of USD 8.22 billion and a revenue forecast in 2030 of USD 24.5 billion. This is a CAGR (compound annual growth rate) of 14.6% from 2022 to 2030. Needless to say, the…