PATTERN_BLUE_1320x780 Blogs
Read article Unraveling the Complexities of Oligonucleotides: Overcoming Analytical Challenges

In the world of scientific research and development, certain analytes pose unique challenges that require specialized expertise to overcome. Oligonucleotides, a class of analytes consisting of short DNA or RNA sequences, are notorious for their complexity and demanding nature. With their increasing importance in the…

KCAS-blog-thumb_2023_Navigating-Growth Blogs
Read article KCAS Growth: Navigating Company Expansion with Integrity and Engagement

Clinical research carries significant risks and numerous obstacles that must be overcome to achieve success. Identifying the ideal Contract…

KCAS-podcast-thumb_TWB-067 Podcasts
Listen to podcast The Weekly Bioanalysis Podcast Eps #67: “Evolution of PK Modalities & the Impact on Regulations”

In the world of bioanalysis, pharmacokinetics is a key step in the process of measuring and identifying elements of the drug. It is a baseline for sample analysis, and in episode 67 of “The Weekly Bioanalysis”, Dom and John discuss the history and evolution drug and pharmacokinetic modalities…

KCAS-podcast-thumb_TWB-066 Podcasts
Listen to podcast The Weekly Bioanalysis Podcast Eps #66: “Recent Advances in Hybrid LC-MS/MS with Special Guests”

Special guests Dawn Duffield, PhD of KCAS and Barry Jones, PhD of Crinetics join John and Dom in the 66th episode of “The Weekly Bioanalysis” to discuss the ways Hybrid LC-MS/MS has advanced in recent years and how the technology has gone from “new” and somewhat obscure to…

KCAS-blog-thumb_2023-03_neuro-diseases Blogs
Read article Hope in motion: Monitoring Drug Efficacy for Neurodegenerative Diseases

Neurodegenerative diseases affect millions worldwide. Fifty million people are living with Alzheimer’s disease or other dementias. Although Alzheimer’s disease is one of the most recognized, it is just one of many neurological disorders, such as Multiple Sclerosis, Parkinson’s, or Huntington’s disease. These conditions lead to a…

KCAS-podcast-thumb_TWB-065 Podcasts
Listen to podcast The Weekly Bioanalysis Podcast Eps #65: “Early Non-clinical Bioanalysis Plays in Your Project”

Dom and John discuss the role early non-clinical bio analysis plays in your project, why it is important, how it has changed over the years, and what might be next for this growing part of the industry. To view/listen to the episode of “the Weekly Bioanalysis” click the…

PATTERN_AMBER_1320x780_3 Blogs
Read article The ICH M10 Guideline as the Gold Standard

ICH M10 (International Committee of Harmonization Multidisciplinary guideline) provides guidance on bioanalytical method validation and study sample analysis for the measurement of chemical and biological human drugs and their metabolites in biological samples. Such pharmacokinetic/toxicokinetic data serve as the basis for regulatory decisions on the safety, dosage, and…

KCAS-blog-thumb_2023_kcas-flow-for-cgt Blogs
Read article Considerations for Molecular Bioanalysis in Support of Cell & Gene Therapies

Being that it is a relatively “niche” segment of the industry, there are several key areas that need to be considered in the field of molecular services related to cell and gene therapies. First and foremost, it is important to recognize that regulatory guidelines within this field are…

KCAS-blog-thumb_2023_02-KCAS-ADCs-with-Hybrid Blogs
Read article Antibody Drug Conjugate Services from KCAS and What Hybrid Technology Contributes

Anyone who has been following KCAS for any amount of time has likely heard us discuss the advantages of Hybrid LC-MS/MS for the bioanalysis of large molecules. As pioneers in the technology for many years, KCAS has become a strong proponent of working with our customers to demonstrate the quality…

PATTERN_AMBER_1320x780_2 Blogs
Read article Guiding the Way: Creating a Roadmap for Your Functional Assays

Understanding the interactions between drugs and biological systems is critical for the success of a new drug. One key tool in this process is functional assays. Functional assays are customized assays that evaluate the impact of drugs on the functionality of cells. They test for a drug’s specific biological mechanism…