PATTERN_AMBER_1320x780 Blogs
Read article GIP & GLP-1 Analogues – More Than Just Weight Loss Drugs

The Pharm/Biotech industry’s main focus is on development of therapeutics to address unmet medical needs but sometimes, clinical trials lead to observations that lead to a change in research path for a drug. A good example is sildenafil that was originally studied for use in hypertension and angina pectoris. Observed…

KCAS-blog-thumb_2023-09A_LBAs-Plethora Blogs
Read article Ligand Binding Assays: a Plethora of Technologies to Address Your Projects’ Requirements

Ligand binding assays (LBAs) have been our core activity for decades. LBAs are commonly used to measure interactions between two proteins, a ligand and its receptor, a monoclonal antibody (mAb) and its target, or biologics and Anti-Drug Antibodies (ADA). Throughout the…

PATTERN_BLUE_1320x780 Blogs
Read article The Evolution of Biodistribution Studies: Deciding Between Qualified vs. Validated Methods

In the ever-evolving landscape of pharmaceutical research, biodistribution studies play a pivotal role in understanding how drugs and therapies are distributed within the body. These studies are critical for assessing the efficacy and safety of new treatments, particularly in the realm of cell…

PATTERN_AMBER_1320x780_2 Blogs
Read article What Can We Learn from Our Tears? Learn About a Recently Published Ocular Study by the Cell & Gene Therapy Department at KCAS

Recently, Matthew Pennington, PhD (one of KCAS’s Senior Scientists) was the senior author on a publication entitled “A Validated Droplet Digital Polymerase Chain Reaction Assay for the Detection of Adeno Associated Viral Vectors in Bio Shedding Studies of Tears”. Below, Matt explains the significance in what they accomplished…

KCAS-podcast-thumb_TWB-069 Podcasts
Listen to podcast Podcast Eps #69: “The Evolving world of Antibody-Drug Conjugates & How KCAS Can Help”

Starting with a description of Antibody Drug Conjugates (or ADCs, for short), Dom and John dive into this field of the industry and discuss the ways these services have changed over time and even how they’ve changed recently. They review the role of ADCs in meeting some of…

KCAS-blog-thumb_2023-08F_Conventional-vs-Spectral Blogs
Read article Unveiling the Future of Flow Cytometry: Conventional vs. Spectral Flow

In the rapidly evolving realm of flow cytometry, conventional flow cytometry is gradually being displaced by its advanced counterpart, spectral flow cytometry. These technologies, each with its unique strengths and applications, have revolutionized the way we analyze cells and particles. Let’s dive…

KCAS-blog-thumb_2023-08D_Soluble-Biomarkers Blogs
Read article Soluble Biomarkers from KCAS: a Global Perspective

A biomarker is a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or biological responses to an exposure or intervention, including therapeutic interventions(1). With the development of innovative and personalized therapies, biomarker tracking is increasingly important to support the clinical development…

PATTERN_AMBER_1320x780_2 Blogs
Read article A Closer Look at Immunophenotyping and its Applications at KCAS

Immunophenotyping has undergone a seismic change in less than two decades as panel sizes have increased in complexity from <10 to >40 colors. Let’s explore how immunophenotyping is transforming the field and how FlowMetric, a KCAS…

KCAS-blog-thumb_2023-07D_Flow-Expansion Blogs
Read article KCAS is Expanding Cutting-Edge Flow Services into Europe – What Does This Mean for You and Your International Projects?

In an exciting development, KCAS, through its subsidiary FlowMetric, is expanding its flow services in Europe. With a history of providing cutting-edge flow services in the EU, KCAS is taking a significant step forward by transitioning services from its Milan, Italy site to…

KCAS-blog-thumb_2023-07B_PK-ADCs Blogs
Read article Recent FDA Guidance for Pharmacokinetics and Antibody Drug Conjugates, and What They Mean for Your Projects at KCAS

With recent guidance released from the FDA, there are changes for PKs (Pharmacokinetics) and ADCs (Antibody Drug Conjugates) that must be clearly understood before making decisions for your drug product testing. ADCs combine the target specificity of monoclonal antibodies with the…

PATTERN_AMBER_1320x780_3 Blogs
Read article The Power of Spectral Flow via the Latest Cytek Aurora Instrumentation at FlowMetric, A KCAS Company

Spectral flow has come a long way in recent years, transforming from a mere whisper of possibility to an essential tool in bioanalysis. Initially gaining traction in academic institutions, it quickly caught the attention…