Neutralizing antibodies (NAbs) are a subset of Anti-drug antibodies (ADAs) that play an important role in understanding the efficacy and safety of a drug product. While most drugs are associated with low risk and do not require a validated NAb assay prior to testing Phase 3 samples, drugs associated with…

In conjunction with Cytek and Bio-Rad, KCAS Bio will host an open house on Tuesday, June 18th from 10:00am to 5:00+pm at: KCAS BioSpring House Innovation Park727 Norristown Road. Lower Gwynedd, PA 19002Parking is Directly Next to Building 4 and Building This packed event includes: Presentations: KCAS Bio, Cytek and Bio-Rad will…

The age of therapeutic conjugation is upon us! Bioanalysis for support of next-generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines, and potentially many other diseases. Recently, we have seen the…

For episode #8 of “The Conversational Flow” podcast, Brian and Adam spend the time discussing Receptor Occupancy Testing in Clinical Trials. Receptor occupancy (RO) assays are important in clinical trials because they provide valuable information about a drug’s binding characteristics and mechanism of action. Our hosts begin by outlining the…

KCAS Bio is excited to invite you to join us this week in San Francisco, CA during AAPS NBC where Nassouh Mourabet will be giving a presentation entitled “Spectral Unmixing Impact Comparison Across Immunophenotyping Panels and Matrices”. Nassouh Mourabet is a Scientist III in the Flow Cytometry department at KCAS…

Those of you attending the 18th annual WRIB meeting in San Antonio, TX are invited to attend a poster presentation being given by members of the KCAS Bio team: Jack Rogers, Jessie Allen, Yoka Thomas, and Cheikh Kane. This project developed and characterized a novel algorithm for automated ISR selection…

Leonard Herzenberg: The father of modern flow cytometry He is considered the father of flow cytometry. He was an interdisciplinary innovator. He was recognized for his social advocacy and mentorship. Leonard Herzenberg was one of the most influential immunologists of his time. Committed to interdisciplinary collaboration and innovation, he…

KCAS Bio continues to expand its global reach and has selected Crux Biolabs (Melbourne, Australia) as its partner in providing harmonized spectral flow cytometry across the US, Europe, and Australia. The alliance enables KCAS Bio and Crux Biolabs to support the global needs of clinical research by offering advanced spectral…

Arguably the most groundbreaking new opportunities for the treatment of disease and injury are Cell and Gene Therapy Products (CGTP) or what the European Medicines Agency (EMA) call Advanced Therapy Medicinal Products (ATMPs). EMA has broken down ATMPs into three main types: Gene therapy medicines: these…

For episode #76 of “The Weekly Bioanalysis”, Dom and John talk about the popular topic of GLP-1 Analogues – these series of recent blockbuster drugs with multiple applications, as well as some of their bioanalytical challenges. First, the guys go over a little bit of the mechanism of action of…

KCAS Bio is attending CYTO2024, the 37th annual Congress of the International Society for the Advancement of Cytometry in Edinburgh, Scotland! A great occasion to explore the latest advancements in cytometry science and to discuss our flow cytometry services with the community. At this edition, Alessandra Roberto, PhD…

Dawn Dufield, PhD is the Scientific Officer for Mass Spectrometry and has been with KCAS Bio since 2018. Before joining KCAS Bio, she worked in the quantitative large and small molecule LC-MS/MS field for Pfizer for over 20 years. Dawn has been a pioneer in the Hybrid LCMS field and…