3d illustration lymphocytes, t cells or cancer cells Blogs
Read article ELISpot Assay: Versatile Applications and Common Challenges to Overcome

ELISpot (Enzyme-linked immunosorbent spot) is an immunoassay-based technique used to quantify cells that are capable of secreting proteins, including cytokines, cytotoxic molecules, and antibodies, when stimulated with the appropriate antigen. Initially designed to monitor the frequency of circulating antigen-specific memory B-cells, it is now commonly used to determine the frequency…

KCAS-podcast-thumb_TWB-071 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #71: “Drug Development and Where Bioanalytical Fits In”

Dom and John have been doing this for a long time (for over 70 episodes now, to be exact), but they felt it might be a good idea to jump back to the very beginning and discuss the overarching concept of the Drug Development process and where it…

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Read article Overcoming Challenges in Bioanalytical Method Transfers

KCAS is a rapidly growing industry leader that continues to increase its vast knowledge surrounding assay transfers not only internally but externally as well.  As KCAS expands as a global leader in the bioanalytical space we have taken our knowledge surrounding internal assay transfers and extended that knowledge to external…

KCAS-podcast-thumb_TCF-002 Podcasts
Listen to podcast Podcast (The Conversational Flow) Eps #2: “How Sample Collection Impacts Flow Cytometry”

For our second episode of “The Conversational Flow” podcast, Brian and Adam felt that the best topic to discuss was that of sample collection, sample processing and the important role it plays in Flow Cytometry analysis. This is an often discussed topic – What is the best way…

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Read article Communication & Responsiveness: How it Helps the Bioanalytical Process

In our daily life we interact with many different people who help us by applying their expertise to deliver things we would otherwise struggle with. Often the differentiator for us, as consumers, is how we feel we’ve been treated by the people who are working on our behalf. The first…

KCAS-podcast-thumb_TWB-070 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #70: “Looking Forward to the 2023 Autumn Conference Season”

It is that time of year once again… the Fall Conference Season! Every industry has its own set of important trade shows and meetings, but for the Pharma, biotech and bioanalytical industries, these conferences are an opportunity for the planet’s leading experts to get together and share the…

PATTERN_BLUE_1320x780_2 November 15 - November 17

Along with a series of studies we plan to present related to our experiences with hybrid LC-MS/MS technology, KCAS will also be presenting on a study where we analyzed a compound that involved looking at urea in plasma and lung fluid (urea, of course, being a biomarker). Urea is endogenous…

HybridLCMS-LargeMolecules November 15 - November 17

For years, Dawn Dufield, PhD and I have been doing our best to get the word out (via as many venues as possible) about KCAS’s unique expertise with hybrid LC-MS/MS. This year’s upcoming EBF meeting in Barcelona is just such an opportunity, and one we are very much looking…

KCAS-podcast-thumb_TCF-001 Podcasts
Listen to podcast Podcast (The Conversational Flow) Eps #1: “Why Does Flow Cytometry Need Its Own Podcast?”

Flow cytometry is a technique used to detect and measure physical and physiological characteristics of a population of cells or particles. Tens of thousands of cells can be quickly examined and the data gathered is processed by a computer. Uses of flow cytometry can included determination of Cellular…

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Read article GIP & GLP-1 Analogues – More Than Just Weight Loss Drugs

The Pharm/Biotech industry’s main focus is on development of therapeutics to address unmet medical needs but sometimes, clinical trials lead to observations that lead to a change in research path for a drug. A good example is sildenafil that was originally studied for use in hypertension and angina pectoris. Observed…

KCAS-blog-thumb_2023-09A_LBAs-Plethora Blogs
Read article Ligand Binding Assays: a Plethora of Technologies to Address Your Projects’ Requirements

Ligand binding assays (LBAs) have been our core activity for decades. LBAs are commonly used to measure interactions between two proteins, a ligand and its receptor, a monoclonal antibody (mAb) and its target, or biologics and Anti-Drug Antibodies (ADA). Throughout the…

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Read article The Evolution of Biodistribution Studies: Deciding Between Qualified vs. Validated Methods

In the ever-evolving landscape of pharmaceutical research, biodistribution studies play a pivotal role in understanding how drugs and therapies are distributed within the body. These studies are critical for assessing the efficacy and safety of new treatments, particularly in the realm of cell…