Originally developed to monitor B cells producing antigen- or pathogen-specific antibodies, the ELISpot assay is widely used for evaluating vaccine-induced wanted immunogenicity. However, thanks to its high sensitivity, it is also a valuable tool for investigating unwanted immunogenicity, expanding its applications beyond traditional vaccine research. Early Applications in Preclinical…

Cell therapy clinical trials present unique challenges when it comes to monitoring both pharmacodynamic (PD) and persistence endpoints. Unlike traditional small molecules or biologics, cell therapies involve living products that interact dynamically with the patient’s immune system. Understanding how these cells persist, expand, and function in vivo is critical for…

Drug discovery is an essential part of the drug development process. Researchers test candidates to identify those suitable for regulated animal studies and, ultimately, clinical trials. Bioanalytical discovery involves assessing a compound’s physiochemical properties,…

For flow cytometry methods, reproducibility and scalability are crucial as programs move from discovery to the clinic. When it comes to maintaining consistent flow cytometry data over time, across different collection sites, or across multiple clinical studies, there are important challenges to consider. Backbone flow cytometry panels – well-characterized, optimized,…