cro-partner-featured Blogs
Read article Identifying Your CRO-Partner for Flow Cytometry Services

For the last decade or so, the outsourcing of crucial research functions by pharmaceutical and biotechnology companies has become increasingly common and has resulted in the rapid growth of the Contract Research Organization (CRO) industry. But the selection of the best CRO partner to work on your critical research programs is not an easy determination and, in this blog, we dive into some of the key drivers behind this decision.

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Read article Clinical Support and Kitting (CSK) Drug Development Solutions for Support of Cell & Gene Therapies

The age of cell and gene therapies (CGTs) is upon us! It has been a long road to get to this time. The first gene therapy trial on humans was performed in 1990 by researchers at the National Institutes of Health. The first FDA approved CGT came in 2017. One…

KCAS-blog-thumb_2022_NonGLP-PreClinical Blogs
Read article Comprehensive Non-GLP Pre-clinical Support Services from KCAS

Although bioanalysis is KCAS’ principal area of expertise, we are always considering how we can build around those capabilities to ensure that we can provide optimal service for our clients. Our current breadth of service enables us to provide a comprehensive approach during non-GLP pre-clinical studies where it is feasible…

cell-staining-featured Blogs
Read article Optimal Cell Staining

Why is Viability Staining so important for flow cytometry analysis? It seems pretty easy, just mix your cells with antibody conjugates, incubate, wash and you are ready to acquire, but actually cell staining for flow cytometry analysis is far from simple, particularly when it comes to the optimal distinguishing of rare cell populations, or in the deciphering of a complex immune response. There are some key considerations to optimizing flow cytometry cell staining and it requires a disciplined approach to understand the impact of certain steps on the staining process. So, how well do you plan and optimize your staining conditions to ensure the highest quality of flow cytometry data? In this blog, we explore some rules of thumb for Good Staining Practices for flow cytometry

KCAS-Blog_Thumbnail-Banner_Oct-IT-month-1-scaled Blogs
Read article What Does the Shift to Cloud-based Data Storage Mean for Our Industry?

Data can be the most important aspect of a GxP organization. Storage complexity and requirements are increasing, and cloud solutions can be an attractive option for maintaining this ever-growing pool of data. When considerations…

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Read article What Sets KCAS Apart When it Comes to Your Bioanalytical Discovery Projects?

As a Senior Director for Discovery in the pharma division at KCAS, I would like people to think of “Bioanalytical Discovery” as a stage in drug development; one where you are doing your final…

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Read article How to Select the Right CRO Vendor to Support Your Project

When I’m asked about the best way to go about selecting a CRO, my mind goes back to my second day at Magellan Laboratories in 1999 when I started my career years ago in this business. I had a customer who told me what it would take to be a…

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Read article KCAS Offers Adaptive, Creative, and Responsive Solutions to COVID-related Supply Chain Issues.

The benevolent COVID virus has brought our industry many “gifts.” One birthday present is like a jelly of the month club subscription, and it’s impacted all Central Labs and providers of Clinical Sample Collection Kits, without discretion: the shifting un-availability of important kit contents, like vacutainers and polypropylene tubes. While…

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Read article What is Hybrid LC-MS/MS and How Can It Benefit You?

What is Hybrid LC-MS/MS? Technically Hybrid LC-MS/MS is a technique that combines an affinity capture step with LC-MS/MS detection. Usually it only requires one antibody, whereas a typical LBA technique will require two. Following affinity capture, it is common to include a digestion step to produce surrogate peptides, which are…

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Read article How to Avoid Getting Lines Crossed with Analysis of Lipid-substituted Peptides at KCAS

Although small molecules represent the majority of compounds in development as drug candidates, there is an increasing tendency to more complex molecular structures to address unmet molecular needs. This has been reflected in the…

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Read article KCAS Answers Common Questions about Dose Formulation Analysis

In its simplest terms, Dose Formulation Analysis (DFA) verifies all solutions used in preclinical toxicology studies. For FDA IND applications, dose formulation analysis is critical. Some companies are unfamiliar with the DFA process or…

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Read article Program Management at KCAS (part 1 of 3) Welcoming Rebecca Wates, Ph.D.

It was early March 2020, the tendons in my right hand were swollen and throbbing, and I was seeking to learn more about off-the-bench careers at CROs and finally retire from pipetting. A few…