Posts by Rathna Veeramachaneni, Ph.D.

Prior to KCAS Bio, Rathna worked at Celerion (NE, USA) and Pfizer (NY, USA) developing quantitative methods for small and large molecules both in the CRO and Pharma space. Rathna received her Ph.D. from Duquesne University (PA, USA) working on Crosslinking combined with qualitative proteomic mass spectrometry to determine the structure of membrane ion channels in multiple conformational states. Rathna has significant expertise in hybrid LC-MS/MS both at the protein and peptide level.

Microscopic illustration of DNA double helix structure, highlighting gene silencing techniques with RNA interference, antisense oligonucleotides, for genetic research applications Blogs
Read article LC-MS Strategies Advancing Oligonucleotide Bioanalysis from Plasma to Tissue

Oligonucleotide therapeutics continue to reshape drug development by targeting disease pathways at the genetic level. Antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and antibody-RNA conjugates (ARCs) are expanding the range of treatable diseases, particularly for targets that were previously considered inaccessible to conventional therapeutics. As these modalities evolve, bioanalytical workflows…