KCAS Bio collaborated with Phenomenex to demonstrate how magnetic bead-enabled hybrid LC-MS workflows are advancing modern bioanalysis for increasingly complex biotherapeutics. The case study explores how magnetic bead-based affinity capture enhances selectivity, sensitivity, and multiplexing, enabling more reliable quantitation of modalities such as monoclonal antibodies, ADCs, fusion proteins, and antibody-oligonucleotide conjugates. It also highlights the practical advantages of hybrid LC-MS workflows, including improved analytical confidence, workflow flexibility, and support for evolving regulatory expectations. Together, KCAS Bio and Phenomenex illustrate how innovative sample preparation technologies help sponsors generate high-quality data and make more informed drug development decisions.
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