PATTERN_AMBER_1320x780 Blogs
Read article Handling the Challenges of Tissues and Non-routine Matrices

A recent trend observed at KCAS is that the bioanalytical needs of our clients’ projects are becoming more complex.  There is increasing focus on monitoring delivery of therapeutics to the target of interest. This…

PATTERN_BLUE_1320x780 Blogs
Read article Is Hybrid LC-MS/MS Emerging as an Equal Partner to LBA for the Analysis of Biotherapeutics?

There has been an increasing focus on large molecule therapeutics and pharmaceutical companies have increasingly aligned their development pipelines in that direction. This has resulted in more biological therapeutics coming to market.  Last year,…

KCAS-blog-thumb_2022_LBA-and-LCMSMS Blogs
Read article Combining the Benefits of LBA and LC-MS/MS for Pharmacodynamics at KCAS

Pharmacodynamics (PD) is defined as the study of the biochemical and physiological effects of drugs and the mechanisms of their actions. Where pharmacokinetics looks at how the organism processes the drug, pharmacodynamics studies how…

KCAS-blog-thumb_Large-Mol-Challenges-p2 Blogs
Read article Large Molecule Therapeutics Challenges and Solutions (part 2)

To read part one of this 2-part series, click here. With increasing focus on large molecule therapeutics and interest in large molecule biomarkers it’s essential to have LC/MS available as a complimentary technology to ligand…

KCAS-blog-thumb_discovery-bioanalysis Blogs
Read article Drug Discovery: an Essential Part of the Drug Development Process

Drug discovery is an essential part of the drug development process. Testing in drug discovery is the mechanism to provide drug candidates that are selected for regulated animal studies and hopefully moving into clinical trials.

PATTERN_ORANGE_1320x780_2 Blogs
Read article Practical Considerations for Implementing a 20-Analyte Biomarker LC-MS/MS Assay

Biomarkers can be defined and utilized for many purposes.  There are disease biomarkers as well as mechanistic or pharmacological biomarkers.  To reduce attrition and better understand a therapeutic, it is essential to be able to monitor the effectiveness of the therapeutic during drug development. Measurement of biomarker levels related to…

KCAS-blog-thumb_biomarker-questions Blogs
Read article Questions to Consider About Your Biomarker Project

I have been studying Biological Markers (biomarkers) for over 25 years, but last 5 years they have exploded and become a key bioanalytical component to a drug’s success. Biomarkers are used to support drug…

KCAS-blog-thumb_Internal-Standards Blogs
Read article Recognizing the Importance of Internal Standards and Workflows in Bioanalytical LC-MS/MS

The workflow for bioanalytical LC-MS/MS requires isolation of analytes of interest from biological samples prior to analysis. This usually involves an extraction procedure ahead of injection into the LC-MS/MS system where the target compounds…

KCAS-blog-thumb_Large-Mol-Challenges Blogs
Read article Large Molecule Therapeutics Challenges and Solutions (part 1)

A recent trend in the pipelines of pharmaceutical companies & biotechs has been a shift to large molecule therapeutics. This presents a challenge for bioanalysis by LC/MS because the molecular weights of the target…

PATTERN_AMBER_1320x780 Webinars
View webinar KCAS Webinar: Addressing the Challenges of Complex Analytes and Matrices in Preparation for Routine Sample Analysis

Join us Tuesday November 10, 2020 at 11am EST| 8am PST| 4pm CET| 5pm CET Bioanalytical liquid chromatography­–mass spectrometry (LC–MS) for small molecules is often referred to as a routine technology. That perception may be true for many drugs, but as pharmaceutical companies move into new areas, more  projects may…

KCAS-blog-thumb_dose-form-analysis Blogs
Read article Successful Dose Formulation Analysis from KCAS

Dose Formulation Analysis is an essential step in regulated nonclinical studies to ensure correct doses are administered to underpin toxicokinetic assessments. Based on years of experience, KCAS has built a stand-alone team dedicated to…

PATTERN_ORANGE_1320x780 Webinars
View webinar KCAS Webinar Archive: “Optimizing Your CRO Selection Process for Pharmaceutical Drug Discovery”

If you missed our webinar on April 22nd of 2020, you can check it out below! Often, when confronted with outsourcing and looking for laboratories for your discovery projects, turnaround times and cost are two very important factors. Quality and reliability of data generated are of course essential as well. How do you…