KCAS-blog-thumb_Internal-Standards Blogs
Read article Recognizing the Importance of Internal Standards and Workflows in Bioanalytical LC-MS/MS

The workflow for bioanalytical LC-MS/MS requires isolation of analytes of interest from biological samples prior to analysis. This usually involves an extraction procedure ahead of injection into the LC-MS/MS system where the target compounds…

KCAS-blog-thumb_Large-Mol-Challenges Blogs
Read article Large Molecule Therapeutics Challenges and Solutions (part 1)

A recent trend in the pipelines of pharmaceutical companies & biotechs has been a shift to large molecule therapeutics. This presents a challenge for bioanalysis by LC/MS because the molecular weights of the target…

PATTERN_AMBER_1320x780 Webinars
View webinar KCAS Webinar: Addressing the Challenges of Complex Analytes and Matrices in Preparation for Routine Sample Analysis

Join us Tuesday November 10, 2020 at 11am EST| 8am PST| 4pm CET| 5pm CET Bioanalytical liquid chromatography­–mass spectrometry (LC–MS) for small molecules is often referred to as a routine technology. That perception may be true for many drugs, but as pharmaceutical companies move into new areas, more  projects may…

KCAS-blog-thumb_dose-form-analysis Blogs
Read article Successful Dose Formulation Analysis from KCAS

Dose Formulation Analysis is an essential step in regulated nonclinical studies to ensure correct doses are administered to underpin toxicokinetic assessments. Based on years of experience, KCAS has built a stand-alone team dedicated to…

PATTERN_ORANGE_1320x780 Webinars
View webinar KCAS Webinar Archive: “Optimizing Your CRO Selection Process for Pharmaceutical Drug Discovery”

If you missed our webinar on April 22nd of 2020, you can check it out below! Often, when confronted with outsourcing and looking for laboratories for your discovery projects, turnaround times and cost are two very important factors. Quality and reliability of data generated are of course essential as well. How do you…

PATTERN_AMBER_1320x780_3 Blogs
Read article An Introduction to KCAS and How We Help Our Clients

Thank you for your interest in learning about KCAS. Founded in 1979, KCAS has become one of the fastest growing Bioanalytical and Biomarker facilities within our industry. KCAS is a progressive growing contract research…

KCAS-blog-thumb_YouCanStillDoItHere-1 Blogs
Read article Trouble with your lab shutting down? You can still do it here.

The long-term economic consequences of the COVID-19 virus are yet to be determined. However, short term it is having major impact on research & drug development so companies are adapting in order to survive.

PATTERN_ORANGE_1320x780_2 Blogs
Read article Analysis of Unstable Small Molecule Therapeutics at KCAS

Pharmacokinetic modeling during the drug development process is essential for determining whether an administered drug substance has the necessary characteristics to meet its intended medical use. Typically for small molecules, this is based on…

PATTERN_BLUE_1320x780_3 Blogs
Read article Powder-to-Report: An Introduction to the Full Suite of Discovery Services at KCAS

There is a new and growing focus on drug development at KCAS. Our clients – both pharma and biotech research organizations – have depended on KCAS to provide bioanalytical services for over four decades.

PATTERN_AMBER_1320x780_3 Blogs
Read article The Advantage of Disease-Specific Custom Panel Biomarkers by LC-MS/MS at KCAS

Biomarkers are key drivers in the drug development process.  Frequently, developing a panel of biomarkers to test a particular mechanism or hypothesis is critical to the success of a drug.  At KCAS, we develop assays for custom panels or individual biomarkers based on client needs and can also assist with…

PATTERN_BLUE_1320x780 Blogs
Read article The Three P’s of Ploidy – Understanding Ploidy and Flow Cytometry

Ploidy is defined as the number of complete chromosome sets in a cell’s nucleus. In animal cells, chromosomes are typically found in pairs and cells are considered diploid. In contrast, plant cells can tolerate higher levels of genome duplication and can exist in various states of polyploidy. Understanding and characterizing ploidy in diverse organisms, from bacteria to mammals, has been greatly facilitated by flow cytometry-based ploidy measurements. Consider these three P’s of ploidy as you decide if ploidy analysis could be a valuable addition to a current or upcoming study.

KCAS-Blog_Thumbnail-Banner_dose-form Blogs
Read article Dose Formulation Analysis: Accurate and On-Time

Dose Formulation Analysis is an essential step in regulated nonclinical studies. Robust analytical methods, rapid turnaround, and efficient communication helps ensure the dose form results for your GLP studies are delivered on time. At…