The NULISA™ / Argo™ HT platform is a new, cutting-edge technology with strong potential in ultra-sensitive biomarker detection and targeted proteomics. You can now watch KCAS Bio’s XTalks webinar to learn more about how we leverage this technology for the analysis of low-abundance biomarkers. Abstract In drug…

This webinar is a collaboration between Sciex and KCAS Bio. Exploring cutting-edge methods for analyzing oligonucleotides in biological matrices. Oligonucleotide therapeutics have gained recent popularity given their vast applications in genetic disorders, cancers and infectious diseases. There are many challenges when developing bioanalytical methods for the quantitation of oligonucleotides, including…

In the evolving landscape of drug development, biomarkers are increasingly vital in driving decisions across preclinical and clinical studies. From patient stratification and efficacy monitoring to safety assessments and pharmacodynamic evaluations, biomarkers are critical tools for reducing development timelines and increasing the likelihood of regulatory success. But with so many…

As the field of biotherapeutics rapidly evolves, the development of advanced conjugated therapies such as Antibody-Drug Conjugates (ADCs), Antibody-RNA Conjugates (ARCs), siRNA/oligos, and antibody-peptide conjugates has gained significant momentum. These next-generation therapeutics offer promising efficacy and safety profiles for treating various conditions, including cancer, rare diseases, and in vaccine development.

In this discussion, our panelists examine oligonucleotide bioanalysis assessment strategies, including quantification via LBA, LC–MS/MS and hybrid assays, as well as the emerging technologies and the future direction of this rapidly evolving field. In 1998, the first oligonucleotide therapy was approved for commercial use and since then many more have…

Webinar Description: Acquire a deeper understanding of Receptor Occupancy (RO) assays as measured by flow cytometry.  We will discuss the fundamental considerations for RO method design, development, and validation.  Within each of these areas, Dr. Evans highlights critical areas of consideration which can impact your ability to robustly quantify Receptor Occupancy within…

Webinar Description: KCAS Bio will present results from a recent validation of two IP panels on the Cytek Aurora in PBMCs. We have analyzed the impact of different fixation buffers on the efficacy of reference controls over time, and we will explore how to help improve workflow standards and process…

Webinar Description: Biomarkers are a critical aspect of bioanalytical testing, as they provide a vast amount of information, from the effects of a drug on the subject to determining the drug’s mechanism of action and the correct dose for a patient. When developing a biomarker, it is important to understand…

As the pharmaceutical industry continues to evolve, so does the technology behind drug development. One of the most groundbreaking advancements in bioanalysis is Hybrid LC-MS/MS technology, which is rapidly becoming the new standard for analyzing Antibody Drug Conjugates (ADCs). KCAS Bio is proud to be at the forefront of this…

In the dynamic field of biotherapeutics, understanding and managing anti-drug antibodies (ADAs) is critical for the success of drug development programs. ADAs can potentially neutralize the efficacy of biotherapeutic drugs, making it essential to have robust testing methodologies in place from the preclinical to clinical stages. KCAS Bio is excited…

In the fast-paced world of drug development, the ability to produce accurate and reproducible data is paramount. That’s why staying updated with the latest best practices in flow cytometry is crucial. Our webinar, “Evolving Best Practices: Considerations for Conventional and Spectral Flow,” dives deep into the rapidly advancing field of…

In the rapidly advancing world of flow cytometry, staying ahead of the curve is essential for driving impactful research and drug development. Our panel discussion, “Evolving Best Practices in High-Complexity Flow Cytometry,” sheds light on the latest developments that can enhance and accelerate your research efforts. Flow cytometry has long…