Early Research Solutions
Ligand Binding Assays continue to be the primary tool used in the biopharmaceutical sciences to quantitate proteins and anti-drug antibodies in biological fluids and tissues in early stage research, but LC-MS/MS can also be used with extremely selective sample enrichment strategies (immunoaffinity) or sensitive chromatographic approaches (microflow) in support of programs during early research stages.
KCAS has decades of experience in early research solutions using LBA and LC-MS/MS
KCAS has dedicated groups in pharmaceutical services to perform early stage rapid method development and analysis, as well as, regulated preclinical and clinical phases, with support offered through NDA submission. We have an arsenal of top of the line instrumentation with a team of experts throughout the company. The unified training within the departments and cross-training between them allows KCAS to have a quick and nimble response to growing demands at any given time point, to meet your project and program needs.
KCAS Early Research Services
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wi…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to th…
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…
Size Exclusion Chromatography (SEC) is a chromatography method that allows for the separation…
Pharmacological activity of a drug molecule is influenced by many factors. The way a molecule…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…