Discovery Solutions
Drug discovery is an essential part of the drug development process. Testing in drug discovery is the mechanism to provide drug candidates that are selected for regulated animal studies and hopefully moving into clinical trials. Bioanalytical drug discovery includes a wide range of tests including assessment of a compound’s physiochemical properties, metabolite screening, bioavailability, toxicity and pharmacokinetics.
KCAS brings the full power of LBA and LC-MS/MS to your Drug Discovery projects
KCAS offers superiors Ligand Binding Assay work – which continues to be the primary tool used in the biopharmaceutical sciences to quantitate proteins and anti-drug antibodies in biological fluids and tissues – but one of KCAS’ core expertise is using bioanalytical LC-MS/MS to support drug discovery, particularly in assessing bioavailability and pharmacokinetic work. We can help with study design and do the actual TK assessment once the bioanalytical data are available.
KCAS Discovery Services
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses r…
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wi…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to th…
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…
Size Exclusion Chromatography (SEC) is a chromatography method that allows for the separation…
Pharmacological activity of a drug molecule is influenced by many factors. The way a molecule…
Time resolved fluorescence (TRF) relies on the use of very specific fluorescent molecules call…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…