Blogs
Antibody-drug conjugates (ADCs) have been conventionally developed for a wide range of oncological applications since the first ADC approval in 2000 by the FDA. Typically, an ADC consists of three main components: antibody, linker conjugate, and therapeutic drug (payload). The mechanism of an ADC involves the antibody binding to a…
Posters & Papers
Discover in this poster presented by Fabien Lavocat at EBF Open Sympoisum 2024 on “Comparative Evaluation of Ligand Binding Assay Platforms for Biomarker Quantification: Critical Considerations for Ensuring Data Quality and Project Success”.
Posters & Papers
Please download this poster, “Automating Selection for Incurred Sample Reanalysis: A Meta-Analytical-Based Algorithm for Error Reduction”
Blogs
A pharmacokinetic (PK) assays evaluate how the body affects a specific substance after administration which includes: absorption, biodistribution, metabolism, and excretion. Preclinical (or non-clinical) PK assays play a crucial role in drug development and typically focus on assessing drug safety and maximum tolerable dose. For the development of pre-clinical…
Podcasts
For episode #76 of “The Weekly Bioanalysis”, Dom and John talk about the popular topic of GLP-1 Analogues – these series of recent blockbuster drugs with multiple applications, as well as some of their bioanalytical challenges. First, the guys go over a little bit of the mechanism of action…
Videos
Dawn Dufield, Ph.D. and Dominic Warrino, Ph.D. discuss their approach to ligand binding assays (LBAs) and hybrid mass spectrometry (Hybrid LC-MS/MS) in this 11-part video series. What Makes a Good CRO for Bioanalysis? Are there any specific technologies that are more useful to have together? What is a…
Blogs
Over the past decade, a continued discussion point has been the idea around analyzing samples on Ligand Binding Assay (LBA) platforms in singlet (one well) versus the standard duplicate analysis (Single sample added to two different wells). In the recent M10 Bioanalytical Method Validation Guideline issued for guidance in…
webinars
For researchers and professionals working in the biopharmaceutical industry, an upcoming Bioanalysis Zone Panel Discussion will offer a unique opportunity to stay informed about the latest advancements in quantitative analysis techniques. Research projects can only succeed when selecting the appropriate biopharmaceutical quantification technique. Staying…
Blogs
Immunoassays are bioanalytical methods that generally use antibodies to detect and quantify specific analytes, often proteins, in biological samples. The process involves the capture of a target protein by an immobilized antibody, followed by its detection with another antibody conjugated either to enzymes, such as phosphatase alkaline or horseradish peroxidase…
Blogs
KCAS is a rapidly growing industry leader that continues to increase its vast knowledge surrounding assay transfers not only internally but externally as well. As KCAS expands as a global leader in the bioanalytical space we have taken our knowledge surrounding internal assay transfers and extended that knowledge to external…
Blogs
With recent guidance released from the FDA, there are changes for PKs (Pharmacokinetics) and ADCs (Antibody Drug Conjugates) that must be clearly understood before making decisions for your drug product testing. ADCs combine the target specificity of monoclonal antibodies with the…
Blogs
Biologics are drugs derived from complex molecules like antibodies. Over the last two decades they have re-emerged as…