CyTOF and spectral flow cytometry are widely used technologies for high-dimensional single cell profiling of immune cells. Both technologies enable multiparameter single-cell analysis, but they differ significantly in how data are generated, how quickly studies can be executed, and how flexible an assay can be tailored for a specific…

Evolving CAR Therapies and the Growing Need for Robust PK/PD Monitoring Chimeric Antigen Receptor (CAR) based therapies are a growing and continuing focus in oncology and autoimmune therapeutic development. They utilize either self (autologous) or donor-derived (allogenic) T cells that are genetically engineered to target and kill cancerous or autoreactive…

Cell-based immunotherapies like Chimeric Antigen Receptor (CAR)-T cell therapy have been transforming the treatment of hematologic malignancies for more than a decade. Several groundbreaking studies (1) have led to a growing interest in applying these cell-based therapies to other T and B cell-mediated diseases.  One emerging application of CARs is…