
Immunogenicity refers to the ability of a substance, such as an antigen or a vaccine, to provoke an immune response in an organism. The recognition of the substance as foreign triggers an immune response, which involves the production of antibodies and the activation of immune cells to fight against or…

Two of the scientific experts from KCAS Bio have been leaders in determining the direction of qPCR and ddPCR technology for the industry. Carrie Vyhlidal, PhD and Jonathan Mercier are both part of the American Association of Pharmaceutical Scientists’ working group for PCR-based methodology, and they have recently…

KCAS established our clinical sample kit (CSK) team in the early 1990s in response to shortcomings we observed in the collection techniques in trials where we were providing bioanalytical support. As the group has evolved, our aim has never been to be the biggest supplier in the industry but rather…

Flow cytometry is a highly sophisticated laboratory technique. Scientists use this procedure to analyze and quantify certain physical and chemical characteristics of cells or particles. In recent years, the prominence of flow cytometry has grown significantly, and understanding why is pivotal. The recognition of the technique’s importance, especially in the…

Clinical Sample Kitting is an immensely important part of many drug development projects, and one that requires the highest level of attention to detail, combined with the experience to ensure each kit is built exactly to specifications. KCAS Bio is the Clinical Kitting expert for your Drug Development needs. KCAS…

Flow cytometry is an extremely valuable tool that has become an indispensable part of modern drug development. This is especially the case in the realm of bioanalytical and biomarker services. However, as is the case with any useful tool, it’s critical to wield flow cytometry skillfully. The accuracy and reliability…

ELISpot (Enzyme-linked immunosorbent spot) is an immunoassay-based technique used to quantify cells that are capable of secreting proteins, including cytokines, cytotoxic molecules, and antibodies, when stimulated with the appropriate antigen. Initially designed to monitor the frequency of circulating antigen-specific memory B-cells, it is now commonly used to determine the frequency…

KCAS is a rapidly growing industry leader that continues to increase its vast knowledge surrounding assay transfers not only internally but externally as well. As KCAS expands as a global leader in the bioanalytical space we have taken our knowledge surrounding internal assay transfers and extended that knowledge to external…

In our daily life we interact with many different people who help us by applying their expertise to deliver things we would otherwise struggle with. Often the differentiator for us, as consumers, is how we feel we’ve been treated by the people who are working on our behalf. The first…

Along with a series of studies we plan to present related to our experiences with hybrid LC-MS/MS technology, KCAS will also be presenting on a study where we analyzed a compound that involved looking at urea in plasma and lung fluid (urea, of course, being a biomarker). Urea is endogenous…

For years, Dawn Dufield, PhD and I have been doing our best to get the word out (via as many venues as possible) about KCAS’s unique expertise with hybrid LC-MS/MS. This year’s upcoming EBF meeting in Barcelona is just such an opportunity, and one we are very much looking…

The Pharm/Biotech industry’s main focus is on development of therapeutics to address unmet medical needs but sometimes, clinical trials lead to observations that lead to a change in research path for a drug. A good example is sildenafil that was originally studied for use in hypertension and angina pectoris. Observed…