2020 was an odd year for everyone. In what felt like just days, it seemed everything had changed and the rules were being rewritten almost daily about how we would all be engaging with one another. We went from racking up travel, hotel stays and airmiles while visiting our customers…

Georges Köhler and César Milstein: The birth of monoclonal antibodies They discovered the technique for monoclonal antibody production. They won the Nobel Prize in Physiology or Medicine in 1984. They directly led to the development of antibody-based therapies for a vast array of health conditions. Since their initial invention…

A pharmacokinetic (PK) assays evaluate how the body affects a specific substance after administration which includes: absorption, biodistribution, metabolism, and excretion. Preclinical (or non-clinical) PK assays play a crucial role in drug development and typically focus on assessing drug safety and maximum tolerable dose. For the development of pre-clinical PK…

Charcot, Gehrig, Hawking: A Journey Through ALS When you hear the names Charcot, Gehrig, and Hawking, what comes to mind? These names are all linked by a shared thread: Amyotrophic Lateral Sclerosis, or ALS. ALS, also known as Charcot disease, is named after Jean-Martin Charcot, a neurologist from the Pitié-Salpêtrière…

The age of therapeutic conjugation is upon us! Bioanalysis for support of next-generation Antibody Drug Conjugates (ADCs) and Antibody siRNA Conjugates (ARCs) have exploded recently due to the efficacy and safety that these therapies offer for immuno-oncology, rare diseases, vaccines, and potentially many other diseases. Recently, we have seen the…

KCAS Bio is excited to invite you to join us this week in San Francisco, CA during AAPS NBC where Nassouh Mourabet will be giving a presentation entitled “Spectral Unmixing Impact Comparison Across Immunophenotyping Panels and Matrices”. Nassouh Mourabet is a Scientist III in the Flow Cytometry department at KCAS…

Those of you attending the 18th annual WRIB meeting in San Antonio, TX are invited to attend a poster presentation being given by members of the KCAS Bio team: Jack Rogers, Jessie Allen, Yoka Thomas, and Cheikh Kane. This project developed and characterized a novel algorithm for automated ISR selection…

Leonard Herzenberg: The father of modern flow cytometry He is considered the father of flow cytometry. He was an interdisciplinary innovator. He was recognized for his social advocacy and mentorship. Leonard Herzenberg was one of the most influential immunologists of his time. Committed to interdisciplinary collaboration and innovation, he…

Arguably the most groundbreaking new opportunities for the treatment of disease and injury are Cell and Gene Therapy Products (CGTP) or what the European Medicines Agency (EMA) call Advanced Therapy Medicinal Products (ATMPs). EMA has broken down ATMPs into three main types: Gene therapy medicines: these…

KCAS Bio is attending CYTO2024, the 37th annual Congress of the International Society for the Advancement of Cytometry in Edinburgh, Scotland! A great occasion to explore the latest advancements in cytometry science and to discuss our flow cytometry services with the community. At this edition, Alessandra Roberto, PhD…

Dawn Dufield, PhD is the Scientific Officer for Mass Spectrometry and has been with KCAS Bio since 2018. Before joining KCAS Bio, she worked in the quantitative large and small molecule LC-MS/MS field for Pfizer for over 20 years. Dawn has been a pioneer in the Hybrid LCMS field and…

Over the past decade, a continued discussion point has been the idea around analyzing samples on Ligand Binding Assay (LBA) platforms in singlet (one well) versus the standard duplicate analysis (Single sample added to two different wells). In the recent M10 Bioanalytical Method Validation Guideline issued for guidance in June…