Posts by Nathan Gulbis

ProteinAGforADA-KCASBio Blogs
Read article Protein A/G Bead Capture for an ADA Assay: Using the Drug’s Structure to Our Advantage 

The challenge  The sponsor asked us to develop and validate an electrochemiluminescence (ECL) ligand binding assay (LBA) to detect anti-drug antibodies (ADA) in human serum to support clinical studies. The therapeutic is a bispecific conjugated fusion protein with two functional domains, FD1 and FD2. Furthermore, FD1 has significant homology…