Posts by Christine Bain, Ph.D.

Christine brings more than 25 years of experience in immunology and coordination of immune monitoring studies in the context of clinical trials in oncology and infectious diseases. She is now in charge of scientific affairs, from the development of internal R&D programs to the implementation of external collaborative projects with our partners.

Highlights From Our AD/PD 2025 Experience Blogs
Read article Highlights From Our AD/PD 2025 Experience

We were happy to participate in the AD/PD™ 2025 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders, held from April 1 to 5, 2025, in Vienna, Austria. The conference was a valuable opportunity to connect with experts, share our experience, and gain insights…

ELISpot Assay: Applications and Challenges Blogs
Read article ELISpot Assay: Applications and Challenges

Initially developed to assess the frequency of circulating antigen-specific Antibody-Secreting Cells (ASC), ELISpot has become a vital tool for quantifying antigen-reactive T-cells by measuring secreted immune mediators such as cytokines or key molecules involved in cell-mediated cytotoxicity. Compared to other assays for monitoring cell-mediated immunity (CMI), such as…

GENERATION OF BLOOD-DERIVED REFERENCE SAMPLES WITH ENDOGENOUS CYTOKINES-slice Posters & Papers
Read article Generation of Blood-Derived Reference Samples with Endogenous Cytokines

Discover innovative insights into bioanalytical method development with our poster, presented by Christine Bain, Ph.D., at ECCO 2025. This work explores the creation and application of reference samples containing endogenous immune mediators—such as cytokines and chemokines—to effectively evaluate the performance of bioanalytical methods. Download the poster now to learn more…

The Science and Beyond at EIP Lisbon Blogs
Read article The Science and Beyond at EIP Lisbon

Last month, Elodie, Magali, and I found ourselves in Lisbon—not for a spring getaway (though the weather was a delightful preview of the season) and certainly not for ultra-trail training (although the city’s hills did give our calves a solid workout!). Instead, we were there for EIP, an event…

What is a Generic PK Assay? Blogs
Read article Use of Generic PK Assays to Support Toxicology Studies for NBE

What is a generic PK assay? A generic pharmacokinetic (PK) assay, also referred to as a universal PK assay for New Biologic Entities (NBE), is used to measure circulating human biotherapeutics—primarily antibody-based—post-administration across various non-human matrices. These assays are particularly beneficial when drug-specific reagents, such as anti-idiotype antibodies, are…

KCAS-blog-thumb_2024-09_Pharmacokinetics Blogs
Read article The Importance of Pharmacokinetics in Drug Development

The Role of Pharmacokinetics (PK) in Drug R&D Pharmacokinetics (PK) is defined as the study of the fate of a new therapeutic entity (NTE) after it is administered into the body of animals or humans. It involves understanding how the drug is absorbed, distributed, metabolized, and eliminated (ADME). Essentially, PK…

KCAS-blog-thumb_2024-05_Lyon-ALS Blogs
Read article ALS Treatments: Progress and Challenges

Charcot, Gehrig, Hawking: A Journey Through ALS When you hear the names Charcot, Gehrig, and Hawking, what comes to mind? These names are all linked by a shared thread: Amyotrophic Lateral Sclerosis, or ALS. ALS, also known as Charcot disease, is named after Jean-Martin Charcot, a neurologist from the Pitié-Salpêtrière…

PGRN_ADPD2024_Poster Posters & Papers
Read article Performance of a method for quantifying progranulin as a target engagement biomarker for azp2006 in progressive supranuclear palsy.

Please download this poster, “Performance of a method for quantifying progranulin as a target engagement biomarker for azp2006 in progressive supranuclear palsy.” PGRN_ADPD2024_PosterDownload…

KCAS-blog-thumb_2024-03A_OlfactoryBiomarkers Blogs
Read article The Power of the Olfactory Sense in Science

In the scientific field, the often neglected fifth sense, the sense of smell, contributes to broadening our understanding of various phenomena, particularly in the field of biomarkers.Here, we will guide you along our lines of thought on the importance of our olfactory sense, and how it contributes to scientific exploration…

KCAS-blog-thumb_2024-AB Blogs
Read article Ultrasensitive Immunoassays: From cutting-edge technological innovation to proof of utility

Immunoassays are bioanalytical methods that generally use antibodies to detect and quantify specific analytes, often proteins, in biological samples. The process involves the capture of a target protein by an immobilized antibody, followed by its detection with another antibody conjugated either to enzymes, such as phosphatase alkaline or horseradish peroxidase…

KCAS-blog-thumb_2023-11A_immunogenicity Blogs
Read article The Role of Immune Profiling for Studying Disease & Therapy Response

Immunogenicity refers to the ability of a substance, such as an antigen or a vaccine, to provoke an immune response in an organism. The recognition of the substance as foreign triggers an immune response, which involves the production of antibodies and the activation of immune cells to fight against or…