Autoimmune and Immunological Services

Autoimmune diseases occur when the immune system, which normally does not attack a person’s own components, produces self-reacting T-cells or circulating antibodies that recognize host proteins, also known as autoantigens. Over 100 autoimmune diseases have been described, creating a critical need for tools that can detect large numbers of autoantibodies with high sensitivity.

KCAS can offer a robust data set for your assay.

Developing a reliable immune cell-based assay requires significant scientific knowledge and optimization time investment. Immune cell-based screens also require precise and consistent handling for repeatable results to reduce variations in assay performance and unreliable data. KCAS has the experience and the expertise to offer you the tools you need for a successful program.

KCAS Autoimmune and Immunological Services

ASSAY TRANSLATION (SPECIES AND FLUIDS)

The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…

Colorimetric Testing

Colorimetric analysis is a method of determining the concentration of a chemical element or ch…

Method Transfer

Methods transferred into a new laboratory need to be re-established for regulatory compliance….

KCAS Large Molecule Solutions

Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…

Bioavailability / Bioequivalence

Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…

KCAS is the discovery support team of choice!

The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…

Our flow cytometry experts can help with your study design and implementation.

Flow cytometry is a technique used to detect and measure physical and chemical characteristics…

Fluorescence Testing

Fluorescence is used mainly for measuring compounds in solution, or in the case of flow cytome…

Hybrid LC-MS/MS (Immunoaffinity LC-MS/MS)

Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…

Immunogenicity Analysis

All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug deve…

Clinical Sample Kits at KCAS are more than just clinical supplies for the collection of PK sam…

KCAS performs a wide variety of luminescence testing.

Luminescence immunoassays use the low-temperature emission of light (as by a chemical or physi…

Method Development

At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…

Method Qualification

A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…

KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…

The discovery phase in drug development requires rapid and reliable data in making key decisio…

PD Analysis is the assistance with design, regulatory requirements and final data interpretati…

Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…

Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…

Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…

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