Accurate pharmacokinetic data starts with confidence that the concentration measured by LC-MS/MS truly reflects what was present in the biological sample at the time of collection. For some small molecules, maintaining that integrity can be challenging. Structural features such as esters, lactones, aldehydes, and thiols may make a compound…

With recent guidance released from the FDA, there are changes for PKs (Pharmacokinetics) and ADCs (Antibody Drug Conjugates) that must be clearly understood before making decisions for your drug product testing. ADCs combine the target specificity of monoclonal antibodies with the…

Tissue and Non-Liquid Matrices (such as cell lines, red blood cells, PBMCs, bone marrow aspirates, and suspension cells) are valuable matrices[] to test for biomarkers (PD) and drug levels (PK). Testing of tissues and…