APA-2025-KCASBio October 6 - October 8

Join KCAS Bio at Applied Pharmaceutical Analysis (APA) 2025, taking place October 6-8 in Cambridge, Massachusetts. This scientific meeting, hosted by The Boston Society features three days of expert-led workshops on Regulated Bioanalysis, Discovery Bioanalysis, and Mechanistic ADME. The Mechanistic ADME track explores innovative topics such as PROTACs, molecular glues,…

Cutting-Edge PK and Immunogenicity Strategies for Next-Generation ADCs, ARCs, and Conjugated Biotherapeutics Webinars
View webinar Cutting-Edge PK and Immunogenicity Strategies for Next-Generation ADCs, ARCs, and Conjugated Biotherapeutics

As the field of biotherapeutics rapidly evolves, the development of advanced conjugated therapies such as Antibody-Drug Conjugates (ADCs), Antibody-RNA Conjugates (ARCs), siRNA/oligos, and antibody-peptide conjugates has gained significant momentum. These next-generation therapeutics offer promising efficacy and safety profiles for treating various conditions, including cancer, rare diseases, and in vaccine development.

Pharmacokinetics vs Pharmacodynamics Blogs
Read article Pharmacokinetics vs Pharmacodynamics: Key Differences in PK vs PD

Understanding the intricate relationship between drugs and the human body is crucial for effective medical treatments. Two fundamental concepts in pharmacology – pharmacokinetics and pharmacodynamics – play pivotal roles in this understanding. This blog post will delve into these concepts, exploring their differences and significance in drug development and clinical…

What is a Generic PK Assay? Blogs
Read article Use of Generic PK Assays to Support Toxicology Studies for NBE

What is a generic PK assay? A generic pharmacokinetic (PK) assay, also referred to as a universal PK assay for New Biologic Entities (NBE), is used to measure circulating human biotherapeutics—primarily antibody-based—post-administration across various non-human matrices. These assays are particularly beneficial when drug-specific reagents, such as anti-idiotype antibodies, are…

KCAS-podcast-thumb_TWB-085 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #85: “Patient-Centric Sampling: Beyond the Clinic and What it Means for Bioanalysis”

Dom and John, the hosts of “The Weekly Bioanalysis”, recently returned from EBF in Barcelona where there was a session on Patient-centric Microsampling, which both of them found fascinating. This inspired both of them to decide it was high time to revisit this part of our industry. In spite of…

KCAS-event-thumb_2024-011_SOT March 16 - March 20

KCAS Bio is excited to announce our participation in the Society of Toxicology (SOT) Annual Meeting and ToxExpo, taking place in Orlando, Florida on March 16th-20th. As one of the largest gatherings of toxicologists and life sciences professionals, this event offers a unique platform to connect with leaders in toxicology…

KCAS-podcast-thumb_TWB-084 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #84: “Small Molecule LC-MS Development and Evolving Approaches to ADC Payloads”

In episode 84 of “The Weekly Bioanalysis”, our special guest, Bryan Parmentier, joins Dom and John to discuss his background and current role at KCAS Bio, offering insights into the field of small molecule method development. He delves into the typical challenges encountered when working with LC-MS analytes, and how…

KCAS-blog-thumb_2024-09_Pharmacokinetics Blogs
Read article The Importance of Pharmacokinetics in Drug Development

The Role of Pharmacokinetics (PK) in Drug R&D Pharmacokinetics (PK) is defined as the study of the fate of a new therapeutic entity (NTE) after it is administered into the body of animals or humans. It involves understanding how the drug is absorbed, distributed, metabolized, and eliminated (ADME). Essentially, PK…

KCAS-podcast-thumb_TWB-080 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #80: “The Rapid Evolution of PCR Assays with Special Guest, Carrie Vyhlidal”

Our hosts, Dom and John, are excited to welcome special guest, Carrie Vyhlidal, to discuss the topic of the 80th episode of “The Weekly Bioanalysis” podcast – The Rapid Evolution of PCR Assays. PCR (or Polymerase Chain Reaction) is like a copying machine for DNA. Scientists have found ways to…

KCAS-podcast-thumb_TWB-079 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #79: “One & Done Therapies: The Landscape of Gene Therapy for Conditions”

The most recent episode of “The Weekly Bioanalysis” podcast is all about genes! The topic was originally inspired by an article entitled “The Coming of Age of One-and-Done Therapies” which jumped out to both of our hosts, Dom and John, and had been on the back burner for a while…

KCAS-event-thumb_2024-07_SFT November 14 - November 15

KCAS Bio is excited to announce our participation in the annual congress of the French Society for Toxicology, taking place on November 14-15 at the Lyon Convention Center. This landmark event, celebrating the 50th anniversary of the French Society of Toxicology will focus on “Evolutions, Innovations, and New Trends in…

KCAS-podcast-thumb_TWB-077 Podcasts
Listen to podcast Podcast (The Weekly Bioanalysis) Eps #77: “Non-GLP Studies from Early PK to Readiness for GLP Tox Studies”

Dom and John welcome special guests, Habibi Goudarzi and Rochelle Burke to episode #77 of “The Weekly Bioanalysis”, where they discuss the progression of bioanalytical needs for non-GLP Studies, from Early PK to readiness for GLP Tox Studies. These specialists from the KCAS Bio team begin with an introduction to…