Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous challenges associated with using LC-MS/MS for the bioanalysis of oligonucleotides that have slowed its utilization for these assays. These include: However, the increased adoption of LC-MS/MS for oligonucleotides…
webinars
This webinar is a collaboration between Sciex and KCAS Bio. Exploring cutting-edge methods for analyzing oligonucleotides in biological matrices. Oligonucleotide therapeutics have gained recent popularity given their vast applications in genetic disorders, cancers and infectious diseases. There are many challenges when developing bioanalytical methods for the quantitation…
webinars
In this discussion, our panelists examine oligonucleotide bioanalysis assessment strategies, including quantification via LBA, LC–MS/MS and hybrid assays, as well as the emerging technologies and the future direction of this rapidly evolving field. In 1998, the first oligonucleotide therapy was approved for commercial use and since then many…
Blogs
Oligonucleotide therapeutics have recently gained popularity as noted by recent increases in regulatory approvals of oligonucleotides as drugs, novel liquid nanoparticle delivery approaches, and on-target specificity. In the development of bioanalytical assays, there are many challenging aspects to consider when quantitating oligonucleotides, such as non-specific binding,…