webinars
ADCs are one of the fastest-growing therapeutic classes in drug development, with 80+ candidates now in the clinical pipeline. But every ADC creates multiple bioanalytical questions: free payload, conjugated payload, total antibody, and beyond. Each requires its own sample prep strategy, extraction decisions, and sensitivity considerations. In this…
News
KCAS Bio’s Ryan Darling, Associate Director of Mass Spectrometry Bioanalysis, will present at the SCIEX Summit 2026 on Wednesday, October 7, as part of Day 2 of the virtual event. Advancing Ultrasensitive Bioanalysis for Complex Modalities Ryan’s presentation, “Ultrasensitive multiplexed bioanalysis of complex modalities using the SCIEX 7500+…
News
KCAS Bio’s Rathna Veeramachaneni, PhD, will join the 4th Annual Virtual Phenomenex BioSymposium on September 15, sharing insights into advanced LC–MS/MS approaches for the bioanalysis of complex antibody conjugates. Advancing Bioanalysis for Complex Antibody Conjugates Rathna’s presentation, “Magnetic Bead-Enabled Hybrid and Enhanced Traditional LC–MS/MS Workflows for the Bioanalysis…
Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous chaAntibody-drug conjugates (ADCs) have become one of the fastest growing classes of targeted therapeutics. By combining the specificity of monoclonal antibodies with highly potent cytotoxic payloads, ADCs are designed…
Posters & Papers
This paper, a collaboration between SCIEX and KCAS Bio, presents comprehensive LC-MS workflows for the quantitative analysis of antibody-drug conjugates (ADCs). Using trastuzumab deruxtecan as a model ADC, the study demonstrates sensitive quantification of free payload, total antibody, and conjugated ADC, highlighting the analytical performance and broad dynamic…
Blogs
Poster Title: Method Development and Validation for the Determination of Two Protein Biomarkers by Multiplexed Online and Offline Hybrid LC-MS/MS in Human Heart Tissue Can you explain your role at KCAS Bio? I am a Scientist 1 at KCAS Bio in the Mass Spectrometry Bioanalysis Method Development group. In…
Blogs
If an analyte is amenable to analysis, it’s difficult to ignore the benefits that LC-MS/MS can provide. There are numerous challenges associated with using LC-MS/MS for the bioanalysis of oligonucleotides that have slowed its utilization for these assays. These include: However, the increased adoption of LC-MS/MS for oligonucleotides…
Posters & Papers
KCAS Bio collaborated with Phenomenex to demonstrate how magnetic bead-enabled hybrid LC-MS workflows are advancing modern bioanalysis for increasingly complex biotherapeutics. The case study explores how magnetic bead-based affinity capture enhances selectivity, sensitivity, and multiplexing, enabling more reliable quantitation of modalities such as monoclonal antibodies, ADCs,…
Posters & Papers
Discover in this poster presented by Rathna Veeramachaneni, Ph.D. at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about the various developmental parameters to consider for fit-for-purpose validation of a novel multiplexed hybrid LC–MS/MS assay for the simultaneous quantitation of two abundant biomarkers in human heart tissue.
Posters & Papers
Discover in this poster presented by Andrew Bergdorf at the American Society for Mass Spectrometry (ASMS) Conference in 2026 about how we developed a streamlined, high-throughput proteomics workflow for human heart tissue that reduces sample preparation time while maintaining robust and reproducible biomarker detection. Key optimizations in…
Posters & Papers
Discover in this poster presented by Amrit Chakravarty, Ph.D. at the AAPS National Biotechnology Conference in 2026 about a high-sensitivity bioanalytical workflow combining single-use tip-based online cleanup on the Evosep Eno platform with a microflow LC-MS/MS setup on a SCIEX Triple Quad 7500+. The approach enables robust…
Videos
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