Platforms - LC-MS/MS Solutions

Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) is a powerful analytical technique that combines the separating power of liquid chromatography with the highly sensitive and selective mass analysis capability of triple quadrupole mass spectrometry. The strength of this technique lies in the separation power of LC for a wide range of compounds combined with the capability of the MS to quantify compounds with a high degree of sensitivity and selectivity based on the unique mass/charge (m/z) transitions of each compound of interest.

KCAS has unparalleled experience with LC-MS/MS

KCAS is uniquely qualified providing LC-MS/MS for bioanalysis. In particular, our scientists are adept in measuring drugs and their metabolites in complex tissues to support drug development. Our experience in supporting both human and animal health programs, along with consulting services, has been a deciding factor of why clients have choosen KCAS.

LC-MS/MS

KCAS LC-MS/MS Services

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The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…

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Methods transferred into a new laboratory need to be re-established for regulatory compliance….

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Aggregate analysis is done to identify potential protein aggregation that can contribute to th…

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The analysis of free amino acids (20 naturally occurring) in plasma or other biological matric…

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A significant number of drugs contain a chiral center that allows the compound to properly fit…

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The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…

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At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…

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A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…

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KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…

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Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small…

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Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…

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Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…

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The discovery phase in drug development requires rapid and reliable data in making key decisio…

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PD Analysis is the assistance with design, regulatory requirements and final data interpretati…

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Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…

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Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to th…

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The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…

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Size Exclusion Chromatography (SEC) is a chromatography method that allows for the separation…

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Pharmacological activity of a drug molecule is influenced by many factors.  The way a molecule…

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Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…

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