Platform - ELISA Solutions
Enzyme-linked immunosorbent assays (ELISA) are the most common methods for LBA (ligand binding assays). KCAS is routinely challenged to improve the lower limit of quantification (LLOQ) of ELISA kits. We have our process fine-tuned and repeatedly provide meaningful biomarker data to our clients.
KCAS Specializes in Optimizing ELISA Kits for Biomarkers
Collectively, the KCAS team has more than 50 years of kit and immunoassay experience and we qualify between 30-40 biomarkers per year. KCAS has a focus on understanding the ever evolving needs of drug development. We have a scientific-focused culture, steadfast values of teamwork and recognition that outsourcing partners today must provide expertise, commitment and endurance, to solve problems with tenacity.
KCAS ELISA Services
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses r…
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Colorimetric analysis is a method of determining the concentration of a chemical element or ch…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
Critical reagents are essential components of analytical methods whose unique characteristics…
Should define what it is first… ie Bridging Validation is a run when one is trying to move fro…
Fluorescence is used mainly for measuring compounds in solution, or in the case of flow cytome…
All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug deve…
Luminescence immunoassays use the low-temperature emission of light (as by a chemical or physi…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
KCAS’ Kit preparation service can provide kits for  sample collection for Pre-Clinical/ Non-Cl…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
KCAS’ Clinical Sample Kit (CSK) service provides clinical sample kits for all phases of clinic…
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…
The Laboratory Collection Manual provides biological sample collection, processing, storage an…
Biomarkers come in many flavors and can be used as alternatives for assessing the functionalit…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…