Posts by Ryan Darling

Ryan Darling is the Associate Director of Mass Spectrometry Bioanalysis at KCAS Bio, bringing over 13 years of experience in the pharmaceutical and CRO industries. His expertise lies in LC-MS method development across a wide range of modalities, including small molecules, proteins, and oligonucleotides, with a particular emphasis on the bioanalysis of antibody-drug conjugates (ADCs) and antibody-RNA conjugates (ARCs). Throughout his career, Ryan has been dedicated to advancing bioanalytical strategies to support complex drug development programs, combining technical innovation with a deep understanding of regulated bioanalysis environments.

Biomarker Analog by Hybrid LC-MSMS_KCAS Bio Posters & Papers
Read article Method Development and Validation of a Biomarker Analog by Hybrid LC-MS/MS with Two-Dimensional Chromatography in Human Matrices
Method Development and Validation of a Biomarker Analog by Hybrid LC-MS/MS with Two-Dimensional Chromatography in Human Matrices

Discover in this poster presented by Ryan Darling at WRIB 2026 on how a validated hybrid immunoaffinity LC–MS/MS method using a surrogate peptide and 2D chromatography enables selective, sub-ng/mL quantitation of a KLK1 analog in human plasma, overcoming LBA limitations caused by near-identical endogenous KLK1. If you have…