Therapeutic-focused CRO Services

KCAS Bio has proven expertise across a range of disease and treatment areas. With more than 45 years of experience as a drug development CRO, we combine deep bioanalytical and biomarker experience with our reputation for consistency, transparency, and data integrity at every stage of your specific therapeutic focus area.

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Therapeutic areas of focus

Allergy & immunology

We have extensive experience in developing, validating, and implementing immunological methods, including biomarker quantification and flow cytometry. Trust our team of experts to provide tailored solutions for your drug development needs.

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Oncology

KCAS Bio provides reliable data to advance immune-oncology treatments. From discovery to Phase III trials, we have experience in flow cytometry, ELISPOTs, and cell-based assays, alongside multiple biomarkers.

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Infectious diseases

In a post-COVID-19 world, trust a CRO with proven experience in infectious disease and vaccine development. KCAS stands ready, equipped with diverse platforms and techniques for your project success.

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Neurological

In a world witnessing a surge in brain disorders, our advanced neurosciences expertise is your ally from discovery to translation. Unlock the potential of neurological drug development with KCAS.

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Gastrointestinal

With a focus on experimental therapeutics, we address a spectrum of conditions including Crohn's disease and inflammatory bowel disease. Trust KCAS for a comprehensive approach to advance your project in the evolving landscape of gastrointestinal disorders.

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Ophthalmology

From compound identification to efficacy studies, we specialize in preclinical ophthalmic research. Our experienced team ensures milestone data accuracy for crucial early-stage decisions. Trust KCAS Bio for the complexities of your ophthalmology study.

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Rare diseases

Our validated 20-plex assay for 20 amino acids supports metabolism and rare disease research. Developing drugs for rare diseases demands specialized expertise, especially in cell and gene therapy. KCAS Bio stands out with a proven history and experience.

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Respiratory

We monitor immune system status during and after infection, offering flow cytometric immunophenotyping, cytokine profiling, and retrospective studies. With expertise in whole blood, PBMCs, and respiratory samples, we specialize in diseases like COPD, lung cancer, and pneumonia.

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Renal

Trust KCAS for expert renal/kidney testing. We develop assays, even for challenging compounds, ensuring quality data for drug development. With extensive experience, we understand the crucial role renal function plays in drug elimination.

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Cardiovascular

With 40+ years in pre-clinical research, we provide deep expertise in cardiovascular biomarkers and large molecule drugs. From target identification to drug development, trust us for comprehensive bioanalytical support at every stage of your cardiovascular drug project.

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Metabolic

Discover comprehensive support for metabolic drug development with KCAS. With a deep understanding of metabolic and endocrine diseases, we provide expert bioanalytical services from discovery to biologic development.

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Method Development and Validation for the Determination of Two Protein Biomarkers by Multiplexed Online and Offline Hybrid LC-MS/MS in Human Heart Tissue Posters & Papers
Read article Method Development and Validation for the Determination of Two Protein Biomarkers by Multiplexed Online and Offline Hybrid LC-MS/MS in Human Heart Tissue

Discover in this poster presented by Taylor Dufield at WRIB 2026 on how a fit-for-purpose multiplex LC–MS/MS workflow combining online and offline anti-peptide immunoprecipitation that enables sensitive, selective quantitation of protein biomarkers and binding partners from a single digested tissue sample across multiple species using a validated ICH M10-aligned approach.

Method Development and Validation of a Biomarker Analog by Hybrid LC-MS/MS with Two-Dimensional Chromatography in Human Matrices Posters & Papers
Read article Method Development and Validation of a Biomarker Analog by Hybrid LC-MS/MS with Two-Dimensional Chromatography in Human Matrices

Discover in this poster presented by Ryan Darling at WRIB 2026 on how a validated hybrid immunoaffinity LC–MS/MS method using a surrogate peptide and 2D chromatography enables selective, sub-ng/mL quantitation of a KLK1 analog in human plasma, overcoming LBA limitations caused by near-identical endogenous KLK1. If you have any questions…

Cytof vs Spectral Flow Cytometry: Overview and Comparison Blogs
Read article Cytof vs Spectral Flow Cytometry: Overview and Comparison

CyTOF and spectral flow cytometry are widely used technologies for high-dimensional single cell profiling of immune cells. Both technologies enable multiparameter single-cell analysis, but they differ significantly in how data are generated, how quickly studies can be executed, and how flexible an assay can be tailored for a specific…

Agile, responsive, and easy to work with

We prepare and adapt our services based on a deep understanding of your drug development ambitions and wider business objectives.

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