Hybrid LC-MS/MS services

Hybrid LC-MS/MS at KCAS Bio delivers advanced, high-sensitivity bioanalytical services for complex and emerging therapeutic modalities.

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Hybrid LC-MS/MS Process

Leveraging our extensive expertise in this technically demanding field, we follow a structured, step-by-step process to ensure rigor and reliability at every step.

  • Step 1: Affinity Enrichment
    The analyte (protein or peptide) is selectively captured using antibody-coated beads or columns to reduce matrix complexity.
  • Step 2 : Enzymatic Digestion
    Captured proteins are digested into surrogate peptides optimized to reflect target structure and sequence.
  • Step 3: LC-MS/MS Detection
    Peptides are separated via chromatography and analyzed by tandem mass spectrometry for high-precision quantitation.
  • Step 4: Data Analysis & Reporting
    Our bioanalytical team interprets data with sequence-level confidence, delivering regulatory-ready reports for submission.

 

 

Tell us how we can help with your project

We've earned our reputation for delivering reliable, error-free data. We understand the importance of speed, flexibility, and consistency and only make promises we can keep.

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