Platforms - Hybrid LC-MS/MS Solutions
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment on beads or columns) with the selectivity and sensitivity provided by LC-MS/MS. Hybrid LC-MS is a complimentary technique to LBA utilized in cases where availability of adequate or optimal reagents are limited. However, there are definite times when this technique has advantages over the traditional LBA, for example when you are translating between species that have different primary sequences.
Put the Power of Hybrid Technology to work for your project at KCAS
KCAS has leading experts who were early pioneers in the field of Hybrid LCMS with over 20 years experience in developing hybrid LCMS assays for proteins and peptides for both biomarkers as well as biotherapeutics. Our wealth of expertise in both LBA and Biopharma LCMS make KCAS a great partner to help clients pick the best technology to answer their questions.

KCAS Hybrid LC-MS/MS Services
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses r…
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Aggregate analysis is done to identify potential protein aggregation that can contribute to th…
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
Critical reagents are essential components of analytical methods whose unique characteristics…
Should define what it is first… ie Bridging Validation is a run when one is trying to move fro…
The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug deve…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small…
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…