Posts by Danton Shoemaker

Locked Nucleic Acids (LNAs) in PCR Assays: Enhanced Sensitivity and Specificity Blogs
Read article Locked Nucleic Acids (LNAs) in PCR Assays: Enhanced Sensitivity and Specificity

Locked Nucleic Acids (LNAs) are RNA analogs that provide more stable Watson-Crick base-pairing. LNA ribonucleotides can be added into RNA and DNA oligonucleotides to increase the affinity of these oligonucleotides for their complementary sequences. In addition, these LNA present oligonucleotides have extraordinary single-nucleotide discrimination as well as enhanced stability, as…