Therapeutic Area - Renal (kidney) Solutions
A large number of drugs are eliminated to a clinically important degree by the kidney. For many drugs, this means that in patients with decreased renal function, doses need to be decreased to avoid exposure of the patient to excessive drug concentrations that may cause toxicity. In general, if 30% or more of a drug’s total clearance is dependent on the kidney, dose reduction should be considered in patients with decreased renal function. Thus, it is important early in drug development to quantify the renal contribution to overall drug elimination.
KCAS knows how important Renal/kidney testing is to your drug development
The team at KCAS has expertise in developing renal/kidney testing that results in quality data for our customers. In fact, KCAS has been called upon in the past to develop challenging assays for our clients who have had issues with the solubility of their compounds in the kidney. Our knowledge and experience allows these customers to continue developing their drugs with a full understanding of the role renal function plays in that development.
KCAS Renal (kidney) Services
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…
The analysis of free amino acids (20 naturally occurring) in plasma or other biological matric…
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wi…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
Clinical Sample Kits at KCAS are more than just clinical supplies for the collection of PK sam…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…