Therapeutic Area - Renal (kidney) Solutions
A large number of drugs are eliminated to a clinically important degree by the kidney. For many drugs, this means that in patients with decreased renal function, doses need to be decreased to avoid exposure of the patient to excessive drug concentrations that may cause toxicity. In general, if 30% or more of a drug’s total clearance is dependent on the kidney, dose reduction should be considered in patients with decreased renal function. Thus, it is important early in drug development to quantify the renal contribution to overall drug elimination.
KCAS knows how important Renal/kidney testing is to your drug development
The team at KCAS has expertise in developing renal/kidney testing that results in quality data for our customers. In fact, KCAS has been called upon in the past to develop challenging assays for our clients who have had issues with the solubility of their compounds in the kidney. Our knowledge and experience allows these customers to continue developing their drugs with a full understanding of the role renal function plays in that development.