Therapeutic Area - Cardiovascular & Metabolic Solutions
A metabolite is the intermediate end product of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g., pigments, odorants, and pheromones). A primary metabolite is directly involved in normal “growth”, development, and reproduction.
KCAS has the experience to help with your project
KCAS has a deep understanding of metabolic and endocrine diseases and the large molecule drugs used to treat them. From discovery through every phase of biologic development, KCAS offers comprehensive bioanalytical support for every stage of your metabolic and cardiovascular drug development.
KCAS Cardiovascular & Metabolic Services
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…
The analysis of free amino acids (20 naturally occurring) in plasma or other biological matric…
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wi…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
Clinical Sample Kits at KCAS are more than just clinical supplies for the collection of PK sam…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…