Platforms - Meso Scale Discovery (ECL) Solutions

The MSD technology enables researchers to profile biomarkers such as cytokines and intracellular signaling proteins, which has a direct impact on the drug discovery process. MSD (Meso Scale Discovery) is a method similar to ELISA except MSD uses electrochemiluminescence (ECL) as a detection technique as opposed to a colormetric reaction employed by ELISA.

KCAS was the first laboratory  to qualify the entire 54 V-PLEX offered by MSD

At KCAS, we perform a wide variety of luminescence testing for single analytes, multiplexed analytes, enzyme activity assays, and cell-based assays for support of non-clinical and clinical PK, PD/Biomarker and Immunogenicity testing. We have the experience and expertise to develop de novo methods or help optimize methods to meet the regulatory guidelines. Our highly trained scientific staff uses MSD to analyze nanogram, picogram, and even femtogram detection levels for PK and biomarkers.

Meso Scale Discovery

KCAS Meso Scale Discovery (ECL) Services

ASSAY TRANSLATION (SPECIES AND FLUIDS)

The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…

Colorimetric Testing

Colorimetric analysis is a method of determining the concentration of a chemical element or ch…

Method Transfer

Methods transferred into a new laboratory need to be re-established for regulatory compliance….

KCAS Large Molecule Solutions

Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…

Aggregate Analysis

Aggregate analysis is done to identify potential protein aggregation that can contribute to th…

Bioavailability / Bioequivalence

Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…

Cell Culture Services

Cell based assays are highly specialized in vitro methods that can evaluate the functional and…

Critical reagents are essential components of analytical methods whose unique characteristics…

Critical Reagents

Should define what it is first… ie Bridging Validation is a run when one is trying to move fro…

KCAS is the discovery support team of choice!

The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…

Our flow cytometry experts can help with your study design and implementation.

Flow cytometry is a technique used to detect and measure physical and chemical characteristics…

Fluorescence Testing

Fluorescence is used mainly for measuring compounds in solution, or in the case of flow cytome…

Immunogenicity Analysis

All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug deve…

KCAS performs a wide variety of luminescence testing.

Luminescence immunoassays use the low-temperature emission of light (as by a chemical or physi…

Method Development

At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…

Method Qualification

A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…

KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…

Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small…

Cell Culture Services

                All biotherapeutics will need to under…

Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…

Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…

KCAS’ Kit preparation service can provide kits for  sample collection for Pre-Clinical/ Non-Cl…

The discovery phase in drug development requires rapid and reliable data in making key decisio…

PD Analysis is the assistance with design, regulatory requirements and final data interpretati…

Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…

Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…

KCAS’ Clinical Sample Kit (CSK) service provides clinical sample kits for all phases of clinic…

The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…

The Laboratory Collection Manual provides biological sample collection, processing, storage an…

Biomarkers come in many flavors and can be used as alternatives for assessing the functionalit…

Time resolved fluorescence (TRF) relies on the use of very specific fluorescent molecules call…

Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…

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