Platform - Ligand Binding Assays
Ligand Binding Assays continue to be the primary tool used in the biopharmaceutical sciences to quantitate proteins and anti-drug antibodies in biological fluids and tissues. This assay platform is a useful tool used from early drug discovery, through pre-clinical toxicology work, and clinical studies.
KCAS has grown to meet the LBA demands of the industry
The Ligand Binding Assay (LBA) team at KCAS is growing to meet changes for support of bioanalytical biopharmaceuticals and biomarker testing. The areas we are seeing the biggest need for growth is in the areas of Immuno-Oncology therapies, cell & gene therapies, monoclonal antibodies and Antibody Drug Conjugates (ADCs). To meet the needs of our customers in this area, our LBA team has more than doubled its size in our new facility.
KCAS Ligand Binding Assay Services
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Colorimetric analysis is a method of determining the concentration of a chemical element or ch…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug to…
Aggregate analysis is done to identify potential protein aggregation that can contribute to th…
Alkaline Hematin Kits are not the ordinary run of the mill clinical supply kit. Collecting for…
Since 2006, the KCAS has provided analytical support to companies developing treatments for me…
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the g…
Cell based assays are highly specialized in vitro methods that can evaluate the functional and…
Critical reagents are essential components of analytical methods whose unique characteristics…
Should define what it is first… ie Bridging Validation is a run when one is trying to move fro…
The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…
Flow cytometry is a technique used to detect and measure physical and chemical characteristics…
Fluorescence is used mainly for measuring compounds in solution, or in the case of flow cytome…
All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug deve…
Luminescence immunoassays use the low-temperature emission of light (as by a chemical or physi…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small…
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
KCAS’ Kit preparation service can provide kits for  sample collection for Pre-Clinical/ Non-Cl…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
KCAS’ Clinical Sample Kit (CSK) service provides clinical sample kits for all phases of clinic…
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…
The Laboratory Collection Manual provides biological sample collection, processing, storage an…
Biomarkers come in many flavors and can be used as alternatives for assessing the functionalit…
Time resolved fluorescence (TRF) relies on the use of very specific fluorescent molecules call…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…