Discovery: In the discovery phase of the drug development pipeline, new drug molecular structures, delivery mechanisms, or simply ideas will be too many to see through every single one of them. The Discovery Group is focused on providing fast turnaround times to testing our clients’ research ideas.
LC-MS/MS: Combined with various sophisticated sample preparation techniques, LC-MS/MS is used to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.Â
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses require. . .
The translation of an assay from Discovery to Preclinical/Clinical is an important part of drug deve. . .
The analysis of free amino acids (20 naturally occurring) in plasma or other biological matrices thr. . .
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the general. . .
A significant number of drugs contain a chiral center that allows the compound to properly fit into. . .
Regulated clinical bioanalysis is a key focus at KCAS. Our data has been used in the approval of ove. . .
Critical reagents are essential components of analytical methods whose unique characteristics are cr. . .
The accelerated pace within industry for quick “go / no-go” decisions in drug development, necessita. . .
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wide ran. . .
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s needs. T. . .
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed to achi. . .
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms. Our. . .
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health progr. . .
The discovery phase in drug development requires rapid and reliable data in making key decisions for. . .
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of drug. . .
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metabolism and. . .
Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to them. Po. . .
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with compounds. . .
Pharmacological activity of a drug molecule is influenced by many factors. The way a molecule is me. . .
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, metabolism. . .