Small Molecule Solutions
In the discovery phase of the drug development pipeline, new drug molecular structures, delivery mechanisms, or simply ideas will be too many to see through every single one of them. The KCAS Discovery Group is focused on providing fast turnaround times to testing our clients’ research ideas.
KCAS has an advanced team of Small Molecule Specialists
Combined with various sophisticated sample preparation techniques, LC-MS/MS is used to meet bioanalytical needs for drug discovery, preclinical, and clinical studies, including bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues.

KCAS Small Molecule Services
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses r…
The translation of an assay from Discovery to Preclinical/Clinical is an important part of dru…
Methods transferred into a new laboratory need to be re-established for regulatory compliance….
Aggregate analysis is done to identify potential protein aggregation that can contribute to th…
The analysis of free amino acids (20 naturally occurring) in plasma or other biological matric…
A significant number of drugs contain a chiral center that allows the compound to properly fit…
Regulated clinical bioanalysis is a key focus at KCAS. Our data has been used in the approval…
The accelerated pace within industry for quick “go / no-go” decisions in drug development, nec…
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wi…
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment…
Clinical Sample Kits at KCAS are more than just clinical supplies for the collection of PK sam…
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s ne…
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed t…
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms…
Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small…
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health…
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for…
KCAS’ Kit preparation service can provide kits for sample collection for Pre-Clinical/ Non-Cl…
The discovery phase in drug development requires rapid and reliable data in making key decisio…
PD Analysis is the assistance with design, regulatory requirements and final data interpretati…
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of…
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metaboli…
KCAS’ Clinical Sample Kit (CSK) service provides clinical sample kits for all phases of clinic…
Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to th…
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with com…
The Laboratory Collection Manual provides biological sample collection, processing, storage an…
Biomarkers come in many flavors and can be used as alternatives for assessing the functionalit…
Pharmacological activity of a drug molecule is influenced by many factors. The way a molecule…
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, meta…