Pharmacokinetic / Toxicokinetic (PK/TK) Analysis

Pharmacokinetic / Toxicokinetic (PK/TK) Analysis

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metabolism and Excretion (ADME) of a small molecule compounds, peptides, and biologics/large molecules. KCAS can support your pharmacokinetic needs with non-compartimental analyses and also working with industry experts in more complex modeling for bioavailability/bioequivalence, receptor occupancy and cut-point determinations.

 

Toxicokinetic (TK) analysis provides bioanalytical support of nonclinical safety and toxicology studies in animals.  The goal of TK is to correlate findings of toxicity with a corresponding level of drug exposure.

KCAS can support a wide range of PK method development and validation for preclinical and clinical PK analysis to assist with drug development. KCAS has expertise in PK analysis and interpretation.  Non compartmental analysis performed by using Watson LIMS.

 

TK studies are most often for new chemical entities and require assays capable of supporting dose ranging studies with large analytical ranges.  The support of TK studies also need to consider that the metabolite(s) of the drug may have dramatically divergent concentration(s) relative to the parent.

 

KCAS can provide the needed PK/TK support for your drug development with expertise in a wide range of biological fluids and tissues