Affinity capture elution (ACE) is a method used in detecting ADA to increase the assay drug toleranc. . .
Aggregate analysis is done to identify potential protein aggregation that can contribute to the over. . .
Alkaline Hematin Kits are not the ordinary run of the mill clinical supply kit. Collecting for Alkal. . .
Since 2006, the KCAS has provided analytical support to companies developing treatments for menorrha. . .
The analysis of free amino acids (20 naturally occurring) in plasma or other biological matrices thr. . .
Antibody drug conjugates (ADCs) remain a popular oncology therapeutic modality. ADC analyses require. . .
The translation of an assay from Discovery to Preclinical/Clinical is an important part of drug deve. . .
Bioavailability (BA) is the percentage that a drug or its pro-drug form is absorbed into the general. . .
Cell based neutralization assays encompass a variety of methods that can be utilized in the developm. . .
Cell based assays are highly specialized in vitro methods that can evaluate the functional and bioch. . .
A significant number of drugs contain a chiral center that allows the compound to properly fit into. . .
Regulated clinical bioanalysis is a key focus at KCAS. Our data has been used in the approval of ove. . .
Colorimetric analysis is a method of determining the concentration of a chemical element or chemical. . .
Critical reagents are essential components of analytical methods whose unique characteristics are cr. . .
Should define what it is first… ie Bridging Validation is a run when one is trying to move from one. . .
The accelerated pace within industry for quick “go / no-go” decisions in drug development, necessita. . .
KCAS provides dose form analysis (DFA) for clinical and non-clinical investigations, with a wide ran. . .
Flow cytometry is a technique used to detect and measure physical and chemical characteristics of a. . .
Fluorescence is used mainly for measuring compounds in solution, or in the case of flow cytometry, b. . .
Hybrid LCMS is a technique which combines an enrichment step (typically an antibody enrichment on be. . .
All biotherapeutics will need to undergo immunogenicity assessment sometime in their drug developmen. . .
Clinical Sample Kits at KCAS are more than just clinical supplies for the collection of PK samples w. . .
Luminescence immunoassays use the low-temperature emission of light (as by a chemical or physiologic. . .
At KCAS, methods are developed with a fit-for-purpose design in mind, based on our Client’s needs. T. . .
A fit-for-purpose approach is used by KCAS in method qualifications. Each method is designed to achi. . .
Methods transferred into a new laboratory need to be re-established for regulatory compliance. The. . .
KCAS has extensive experience in validating methods in a wide range of bioanalytical platforms. Our. . .
Multi-plex analysis of biomarkers is a powerful tool for screening of many analytes in a small volum. . .
Neutralizing Antibody (NAB) Studies . . .
Regulated clinical bioanalysis is a key focus at KCAS, supporting both human and animal health progr. . .
Non-clinical (or often referred to as preclinical studies) non GLP samples are often used for biomar. . .
KCAS’ Kit preparation service can provide kits for sample collection for Pre-Clinical/ Non-Clinical. . .
The discovery phase in drug development requires rapid and reliable data in making key decisions for. . .
PD Analysis is the assistance with design, regulatory requirements and final data interpretation. Of. . .
Biomarkers come in many favors. They can vary from serum/plasma analytes to the measurement of drug. . .
Pharmacokinetics (PK) is the determination of the extent of Absorption, Distribution, Metabolism and. . .
KCAS’ Clinical Sample Kit (CSK) service provides clinical sample kits for all phases of clinical tri. . .
Polymeric conjugates are polymer backbones used as delivery systems for drugs conjugated to them. Po. . .
The extent to which a drug binds to plasma proteins can range from neglible to 99.9+% with compounds. . .
The Laboratory Collection Manual provides biological sample collection, processing, storage and ship. . .
Biomarkers come in many flavors and can be used as alternatives for assessing the functionality of t. . .
Size Exclusion Chromatography (SEC) is a chromatography method that allows for the separation of mac. . .
The analysis of a class of lipids referred to as glycosphingolipids (GSL’s). This class of lipids i. . .
Pharmacological activity of a drug molecule is influenced by many factors. The way a molecule is me. . .
Time resolved fluorescence (TRF) relies on the use of very specific fluorescent molecules called lan. . .
Tissue bioanalysis is an essential area in understanding the extent of drug distribution, metabolism. . .