A biomarker is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.
A biomarker can be a traceable substance that is introduced into an organism as a means to examine organ function or other aspects of health.
It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may indicate an infection. More specifically, a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, or with the susceptibility of the disease to a given treatment.
Biomarkers used for medicine are typically categorized as either prognostic or predictive. Prognostic biomarkers indicate the likelihood of patient outcome regardless of a specific treatment. Predictive biomarkers are used to help optimize ideal treatments, and indicates the likelihood of benefiting from a specific therapy.
- Flow Cytometry
- Clinical Sample Analysis
- Method Development
- Pharmacodynamic (PD) Biomarkers
- Pharmacokinetic / Toxicokinetic (PK/TK) Analysis
- Targeted Metabolite ID
- Non-Clinical GLP Sample Analysis
- Aggregate Analysis
- Size Exclusion Chromatography (SEC)
- Chiral Assay Development, Qualification & Validation
- Alkaline Hematin Testing
- Critical Reagent Characterization
- Pharmacodynamic (PD) Analysis
- Hybrid LC-MS/MS (Immunoaffinity LC-MS/MS)
- Method Qualification
- Critical Reagents
- Method Transfer
- Method Validation
- Neutralizing Antibody (NAB) Studies
- Polymeric Conjugate Testing
- Tissue Bioanalysis
- Multi-Plex Analysis
- Non-GLP Sample Analysis