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The workflow for bioanalytical LC-MS/MS requires isolation of analytes of interest from biological samples prior to analysis. This usually involves an extraction procedure ahead of injection into the LC-MS/MS system where the target compounds are separated from other analytes & potential matrix co-extractants. Addition of …

Recognizing the Importance of Internal Standards and Workflows in Bioanalytical LC-MS/MS Read More »

A recent trend in the pipelines of pharmaceutical companies & biotechs has been a shift to large molecule therapeutics. This presents a challenge for bioanalysis by LC/MS because the molecular weights of the target analytes are well beyond the mass range of the mass spectrometer. …

Large Molecule Therapeutics Challenges and Solutions (part 1) Read More »

Join us Tuesday November 10, 2020 at 11am EST| 8am PST| 4pm CET| 5pm CET       Bioanalytical liquid chromatography­–mass spectrometry (LC–MS) for small molecules is often referred to as a routine technology. That perception may be true for many drugs, but as pharmaceutical …

KCAS Webinar: Addressing the Challenges of Complex Analytes and Matrices in Preparation for Routine Sample Analysis Read More »

Dose Formulation Analysis is an essential step in regulated nonclinical studies to assure that correct doses have been administered to underpin toxicokinetic assessments. Based on years of experience, KCAS has built a stand-alone team dedicated to dose form analysis. We recognize that robust analytical methods, …

Successful Dose Formulation Analysis from KCAS Read More »

The Biotherapeutics industry is rapidly modifying and developing new Biotherapeutics into complex molecules with multi-functional domains for specific biological functions. Immunogenicity testing is now mandatory part of any Biotherapeutic development.   Immunogenicity is the ability of an antigen or epitope to elicit an immune response …

Communication & Responsiveness: How it Helps the Bioanalytical Process Read More »

If you missed our webinar on April 22nd of 2020, you can check it out below!     Often, when confronted with outsourcing and looking for laboratories for your discovery projects, turnaround times and cost are two very important factors. Quality and reliability of data generated are of course …

KCAS Webinar Archive: “Optimizing Your CRO Selection Process for Pharmaceutical Drug Discovery” Read More »