Lansoprazole

 

 

 

 

 

Method: LC-MS/MS

Matrix: Human Plasma

Anticoagulant: Sodium Heparin

Storage Temperature: -20 °C

LLOQ: 0.25 ng/mL

ULOQ: 300 ng/mL

Sample Volume: 500 mcL

Precision and Accuracy:

  • LLOQ QC: 11.5% CV; 4.0% Bias
  • Low QC: 7.8% CV; 2.0% Bias
  • Mid QC: 7.3% CV; 4.1% Bias
  • High QC: 7.9% CV; -6.9% Bias
  • Above Range QC (5x Dilution): 8.4% CV; -13.5% Bias

Stability:

  • Short-Term (Bench-Top): 4 hours
  • Long-Term: 9.5 months at -20 °C
  • Freeze/Thaw Cycles: 3

Comments: Validated in presence of Omeprazole

Method Number: V1879P1